Protein Summary
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least i ...more
- ENST00000341115
- ENSP00000342698
- ENSG00000055732
- ENST00000370589
- ENSP00000359621
- TRPML3
- TRP-ML3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.74 | ||
histone modification site profile | 0.61 | ||
PubMedID | 0.61 | ||
tissue sample | 0.56 | ||
transcription factor perturbation | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.94 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 129 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.94 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 129 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 153
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (153)
Protein-Protein Interactions (87)
MCOLN1
Family: IC
Novelty: 0.00442768
p_int: 0.999999167
p_ni: 7.87e-7
p_wrong: 4.6e-8
Score: 0.22
Data Source: BioPlex,STRINGDB
KCNQ5
Family: IC
Novelty: 0.01271842
p_int: 0.99984049
p_ni: 0.000110584
p_wrong: 0.000048926
Score: 0.184
Data Source: BioPlex,STRINGDB
ATP13A2
Family: Transporter
Novelty: 0.00623191
p_int: 0.999695385
p_ni: 0.000304615
Data Source: BioPlex
DAGLA
Family: Enzyme
Novelty: 0.00959313
p_int: 0.999638721
p_ni: 0.00000454
p_wrong: 0.000356739
Score: 0.188
Data Source: BioPlex,STRINGDB
GABRB3
Family: IC
Novelty: 0.00485997
p_int: 0.999536364
p_ni: 0.000454116
p_wrong: 0.000009519
Score: 0.177
Data Source: BioPlex,STRINGDB
TMEM59L
Novelty: 0.22745646
p_int: 0.999398756
p_ni: 0.000576239
p_wrong: 0.000025005
Data Source: BioPlex
TUSC3
Novelty: 0.01388722
p_int: 0.999361562
p_ni: 0.000638435
p_wrong: 3e-9
Data Source: BioPlex
COA1
Family: Enzyme
Novelty: 0.49194068
p_int: 0.999062471
p_ni: 0.000937513
p_wrong: 1.6e-8
Data Source: BioPlex
ATP2A3
Family: Transporter
Novelty: 0.0090982
p_int: 0.998287534
p_ni: 0.001712466
Data Source: BioPlex
ABHD16A
Family: Enzyme
Novelty: 0.04797219
p_int: 0.996462887
p_ni: 0.000220048
p_wrong: 0.003317065
Score: 0.177
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Ion channel transport | ||||
Reactome | Stimuli-sensing channels | ||||
Reactome | TRP channels | ||||
Reactome | Transport of small molecules | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Ion channel transport | ||||
Stimuli-sensing channels | ||||
TRP channels | ||||
Transport of small molecules | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (3)
Components (6)
Processes (3)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
hair color | 1 | 1 | 0 | 1.1 | 40.7 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
hair color | 0 | 1.1 | 40.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | mucolipin 3 | 710987 | ||||||
Mouse | MGI:1890500 | 171166 | ||||||
Rat | RGD:1308420 | 308022 | ||||||
Horse | mucolipin 3 | VGNC:20043 | 100064441 | |||||
Cow | mucolipin 3 | VGNC:31320 | 514345 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | mucolipin 3 | |||||
Mouse | ||||||
Rat | ||||||
Horse | mucolipin 3 | |||||
Cow | mucolipin 3 | |||||
Publication Statistics
PubMed Score 30.94
PubMed score by year
PubTator Score 19.46
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (22)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
---|