You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
MCOLN3
Mucolipin-3

Protein Summary
Description
Nonselective ligand-gated cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:18369318, PubMed:19497048, PubMed:19522758, PubMed:19885840, PubMed:29106414). Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway (PubMed:21245134). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth (By similarity). Involved in the regulation of autophagy (PubMed:19522758). Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341115
  • ENSP00000342698
  • ENSG00000055732
  • ENST00000370589
  • ENSP00000359621

Symbol
  • TRPML3
  • TRP-ML3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.74
histone modification site profile
0.61
PubMedID
0.61
tissue sample
0.56
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.94   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.94   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 153
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (87)
MCOLN1
Tchem
Family:  IC
Novelty:  0.00442768
p_int:  0.999999167
p_ni:  7.87e-7
p_wrong:  4.6e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
KCNQ5
Tclin
Family:  IC
Novelty:  0.01271842
p_int:  0.99984049
p_ni:  0.000110584
p_wrong:  0.000048926
Score:  0.184
Data Source:  BioPlex,STRINGDB
ATP13A2
Tbio
Family:  Transporter
Novelty:  0.00623191
p_int:  0.999695385
p_ni:  0.000304615
Data Source:  BioPlex
DAGLA
Tchem
Family:  Enzyme
Novelty:  0.00959313
p_int:  0.999638721
p_ni:  0.00000454
p_wrong:  0.000356739
Score:  0.188
Data Source:  BioPlex,STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
p_int:  0.999536364
p_ni:  0.000454116
p_wrong:  0.000009519
Score:  0.177
Data Source:  BioPlex,STRINGDB
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.999398756
p_ni:  0.000576239
p_wrong:  0.000025005
Data Source:  BioPlex
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.999361562
p_ni:  0.000638435
p_wrong:  3e-9
Data Source:  BioPlex
COA1
Tbio
Family:  Enzyme
Novelty:  0.49194068
p_int:  0.999062471
p_ni:  0.000937513
p_wrong:  1.6e-8
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.998287534
p_ni:  0.001712466
Data Source:  BioPlex
ABHD16A
Tchem
Family:  Enzyme
Novelty:  0.04797219
p_int:  0.996462887
p_ni:  0.000220048
p_wrong:  0.003317065
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
40.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mucolipin 3
710987
Mouse
MGI:1890500
171166
Rat
RGD:1308420
308022
Horse
mucolipin 3
VGNC:20043
100064441
Cow
mucolipin 3
VGNC:31320
514345
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mucolipin 3
Mouse
Rat
Horse
mucolipin 3
Cow
mucolipin 3
Publication Statistics
PubMed Score 30.94
PubMed score by year
PubTator Score 19.46
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title