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Tchem
MCOLN2
Mucolipin-2

Protein Summary
Description
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19940139, PubMed:19885840). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284027
  • ENSP00000284027
  • ENSG00000153898
  • ENST00000370608
  • ENSP00000359640

Symbol
  • TRPML2
  • TRP-ML2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
histone modification site profile
0.6
phenotype
0.57
tissue
0.49
PubMedID
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.55   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.55   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (65)
LETMD1
Tbio
Novelty:  0.02790517
p_int:  0.999999385
p_ni:  6.15e-7
Data Source:  BioPlex
LY6D
Tbio
Novelty:  0.07032941
p_int:  0.9999983
p_ni:  8e-7
p_wrong:  9.01e-7
Data Source:  BioPlex
SHPK
Tbio
Family:  Kinase
Novelty:  0.16166855
p_int:  0.99988748
p_ni:  0.00011252
Data Source:  BioPlex
SOGA3
Tdark
Novelty:  2.17187131
p_int:  0.999608838
p_ni:  0.000389038
p_wrong:  0.000002124
Data Source:  BioPlex
MCOLN1
Tchem
Family:  IC
Novelty:  0.00442768
p_int:  0.999472318
p_ni:  0.00003276
p_wrong:  0.000494922
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.988671756
p_ni:  0.000001075
p_wrong:  0.011327169
Score:  0.258
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.979071393
p_ni:  0.016993435
p_wrong:  0.003935172
Data Source:  BioPlex
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.978411839
p_ni:  0.0215881
p_wrong:  6.1e-8
Data Source:  BioPlex
MAN2A2
Tbio
Family:  Enzyme
Novelty:  0.07098345
p_int:  0.967160549
p_ni:  0.032807889
p_wrong:  0.000031562
Data Source:  BioPlex
STX16
Tbio
Novelty:  0.02462523
p_int:  0.95879442
p_ni:  0.000907739
p_wrong:  0.040297841
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
TRP channels
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
3
90.4
hair color
1
1
0
1.1
40.7
BMI-adjusted waist circumference
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
90.4
hair color
0
1.1
40.7
BMI-adjusted waist circumference
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mucolipin 2
VGNC:1313
456981
Macaque
mucolipin 2
710909
Mouse
MGI:1915529
68279
Rat
RGD:1308884
292168
Horse
mucolipin 2
VGNC:20042
100052719
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mucolipin 2
Macaque
mucolipin 2
Mouse
Rat
Horse
mucolipin 2
Publication Statistics
PubMed Score 19.55
PubMed score by year
PubTator Score 12.22
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title