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Tchem
MCOLN1
Mucolipin-1

Protein Summary
Description
Nonselective cation channel probably playing a role in the regulation of membrane trafficking events and of metal homeostasis. Proposed to play a major role in Ca(2+) release from late endosome and lysosome vesicles to the cytoplasm, which is important for many lysosome-dependent cellular events, including the fusion and trafficking of these organelles, exocytosis and autophagy (PubMed:11013137, PubMed:12459486, PubMed:15336987, PubMed:14749347, PubMed:29019983). Required for efficient uptake of large particles in macrophages in which Ca(2+) release from the lysosomes triggers lysosomal exocytosis. May also play a role in phagosome-lysosome fusion (By similarity). Involved in lactosylceramide trafficking indicative for a role in the regulation of late endocytic membrane fusion/fission events (PubMed:16978393). By mediating lysosomal Ca(2+) release is involved in regulation of mTORC1 signaling and in mTOR/TFEB-dependent lysosomal adaptation to environmental cues such as nutrient levels ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264079
  • ENSP00000264079
  • ENSG00000090674

Symbol
  • ML4
  • ML1
  • ML4
  • MG-2
  • MLIV
  • MST080
  • TRPML1
  • MSTP080
  • TRP-ML1
  • TRPM-L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
molecular function
0.81
cellular component
0.8
transcription factor binding site profile
0.78
tissue sample
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.77   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.77   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (16)
CHEMBL4870275
Rendered image for CHEMBL4870275
CHEMBL4857820
Rendered image for CHEMBL4857820
CHEMBL4851134
Rendered image for CHEMBL4851134
SF-22
Rendered image for SF-22
SF-51
Rendered image for SF-51
CHEMBL4856175
Rendered image for CHEMBL4856175
CHEMBL4875551
Rendered image for CHEMBL4875551
CHEMBL4847300
Rendered image for CHEMBL4847300
Protein-Protein Interactions (87)
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999999167
p_ni:  7.87e-7
p_wrong:  4.6e-8
Score:  0.22
Data Source:  BioPlex,STRINGDB
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999998962
p_ni:  0.000001001
p_wrong:  3.7e-8
Score:  0.161
Data Source:  BioPlex,STRINGDB
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.999996525
p_ni:  0.000003341
p_wrong:  1.34e-7
Data Source:  BioPlex
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.999980798
p_ni:  0.000016168
p_wrong:  0.000003034
Data Source:  BioPlex
MCOLN2
Tchem
Family:  IC
Novelty:  0.05195244
p_int:  0.999472318
p_ni:  0.00003276
p_wrong:  0.000494922
Data Source:  BioPlex
LY6D
Tbio
Novelty:  0.07032941
p_int:  0.996870405
p_ni:  0.000010111
p_wrong:  0.003119484
Data Source:  BioPlex
CLEC2B
Tbio
Novelty:  0.06581244
p_int:  0.92648181
p_ni:  0.000146068
p_wrong:  0.073372122
Data Source:  BioPlex
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
Score:  0.783
Data Source:  STRINGDB
TRPM1
Tchem
Family:  IC
Novelty:  0.00822899
Score:  0.77
Data Source:  STRINGDB
NEU3
Tchem
Family:  Enzyme
Novelty:  0.00746819
Score:  0.75
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Iron uptake and transport
Reactome
Stimuli-sensing channels
Reactome
TRP channels
Reactome
Transferrin endocytosis and recycling
Name
Explore in Pharos
Explore in Source
Ion channel transport
Iron uptake and transport
Stimuli-sensing channels
TRP channels
Transferrin endocytosis and recycling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (28)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
3
1
3
62.8
electrocardiography
1
1
20
61.8
opioid overdose severity measurement
1
1
1
58.1
mean platelet volume
1
1
1
43.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
left ventricular structural measurement
3
62.8
electrocardiography
20
61.8
opioid overdose severity measurement
1
58.1
mean platelet volume
1
43.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mucolipin 1
VGNC:2317
455656
Macaque
mucolipin 1
703775
Mouse
MGI:1890498
94178
Rat
RGD:1308953
288371
Dog
mucolipin 1
VGNC:43090
611517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mucolipin 1
Macaque
mucolipin 1
Mouse
Rat
Dog
mucolipin 1
Publication Statistics
PubMed Score 326.77
PubMed score by year
PubTator Score 172.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title