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Tbio
MCMBP
Mini-chromosome maintenance complex-binding protein

Protein Summary
Description
Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360003
  • ENSP00000353098
  • ENSG00000197771
  • ENST00000369077
  • ENSP00000358073

Symbol
  • C10orf119
  • MCM-BP
  • C10orf119
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.84
histone modification site profile
0.83
transcription factor binding site profile
0.83
microRNA
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.13   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
MCM3
Tbio
Novelty:  0.00593382
p_int:  0.999999726
p_ni:  2.74e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
MCM5
Tbio
Novelty:  0.00716583
p_int:  0.999999383
p_ni:  6.17e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
DCAF12
Tbio
Novelty:  0.15472702
p_int:  0.999856937
p_ni:  0.000143063
Score:  0.29
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.999710165
p_ni:  0.000289835
Data Source:  BioPlex
SUV39H1
Tchem
Family:  Epigenetic
Novelty:  0.00417439
p_int:  0.999544235
p_ni:  0.000455765
Score:  0.16
Data Source:  BioPlex,STRINGDB
WDR55
Tdark
Novelty:  0.51900003
p_int:  0.999482539
p_ni:  0.000517461
Data Source:  BioPlex
C1QTNF2
Tbio
Novelty:  0.18607978
p_int:  0.999469357
p_ni:  0.000530643
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.998494208
p_ni:  0.001505791
p_wrong:  1e-9
Data Source:  BioPlex
RHPN1
Tbio
Novelty:  0.05722992
p_int:  0.9882617
p_ni:  0.011738293
p_wrong:  8e-9
Score:  0.214
Data Source:  BioPlex,STRINGDB
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.977661444
p_ni:  0.022338556
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
0
1.6
71.6
testosterone measurement
2
1
2
54.4
mean reticulocyte volume
1
1
1
49.5
mean corpuscular volume
1
1
1
46.5
1
1
1
35
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.6
71.6
testosterone measurement
2
54.4
mean reticulocyte volume
1
49.5
mean corpuscular volume
1
46.5
1
35
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex binding protein
VGNC:4744
450781
Macaque
minichromosome maintenance complex binding protein
704028
Mouse
MGI:1920977
210711
Rat
RGD:1306730
309009
Dog
minichromosome maintenance complex binding protein
612966
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex binding protein
Macaque
minichromosome maintenance complex binding protein
Mouse
Rat
Dog
minichromosome maintenance complex binding protein
Publication Statistics
PubMed Score 9.13
PubMed score by year
PubTator Score 5.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title