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Tbio
MCM8
DNA helicase MCM8

Protein Summary
Description
Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Probably by regulating HR, plays a key role during gametogenesis (By similarity). Stabilizes MCM9 protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265187
  • ENSP00000265187
  • ENSG00000125885
  • ENST00000378883
  • ENSP00000368161
  • ENST00000378886
  • ENSP00000368164
  • ENST00000378896
  • ENSP00000368174
  • ENST00000610722
  • ENSP00000478141

Symbol
  • C20orf154
  • POF10
  • C20orf154
  • dJ967N21.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.9
virus perturbation
0.79
protein domain
0.73
phenotype
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.84   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 249   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.84   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 249   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (192)
MCM9
Tbio
Family:  Enzyme
Novelty:  0.0390791
p_int:  0.999998896
p_ni:  0.000001103
p_wrong:  1e-9
Score:  0.988
Data Source:  BioPlex,STRINGDB
MLH1
Tbio
Novelty:  0.00034212
p_int:  0.996713204
p_ni:  0.003286787
p_wrong:  9e-9
Score:  0.65
Data Source:  BioPlex,STRINGDB
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.994667984
p_ni:  0.005332015
p_wrong:  2e-9
Data Source:  BioPlex
VWA5A
Tbio
Novelty:  0.0802354
p_int:  0.994621988
p_ni:  0.005378008
p_wrong:  5e-9
Data Source:  BioPlex
F9
Tchem
Family:  Enzyme
Novelty:  0.00032127
p_int:  0.990904251
p_ni:  0.009095749
Data Source:  BioPlex
LRRC27
Tdark
Novelty:  2.37640076
p_int:  0.985223541
p_ni:  0.014776385
p_wrong:  7.4e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.972293131
p_ni:  0.027706869
Data Source:  BioPlex
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.97036082
p_ni:  0.02963918
Data Source:  BioPlex
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
p_int:  0.968414668
p_ni:  0.031585299
p_wrong:  3.3e-8
Data Source:  BioPlex
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.965551343
p_ni:  0.034448657
Score:  0.16
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (28)
Activation of ATR in response to replication stress (R-HSA-176187)

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Find Similar Targets
Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Reactome
CDT1 association with the CDC6:ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (21)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
4
3
5
97.2
1
1
0
1.2
42.3
anti-Mullerian hormone measurement
1
1
1
39.6
Menorrhagia
1
1
0
1.2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menopause
5
97.2
0
1.2
42.3
anti-Mullerian hormone measurement
1
39.6
Menorrhagia
0
1.2
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance 8 homologous recombination repair factor
VGNC:9882
747729
Macaque
minichromosome maintenance 8 homologous recombination repair factor
718247
Mouse
MGI:1913884
66634
Rat
RGD:1305218
296178
Dog
minichromosome maintenance 8 homologous recombination repair factor
VGNC:43088
477163
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance 8 homologous recombination repair factor
Macaque
minichromosome maintenance 8 homologous recombination repair factor
Mouse
Rat
Dog
minichromosome maintenance 8 homologous recombination repair factor
Publication Statistics
PubMed Score 47.84
PubMed score by year
PubTator Score 18.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title