Tbio MCM5 DNA replication licensing factor MCM5

Protein Summary

Description

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (By similarity). Interacts with MCMBP. The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33992
• O60785
• Q14578
• Q9BTJ4
• Q9BWL8

Gene Name

• MCM5

Ensembl ID

• ENST00000216122
• ENSP00000216122
• ENSG00000100297

Symbol

• CDC46
• CDC46
• MGORS8
• P1-CDC46

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
transcription factor perturbation	0.98
molecular function	0.95
protein domain	0.85
gene perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Replication Licensing Factor Mcm5

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / Dna Replication Licensing Factor Mcm5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.46   (req: < 5)

Gene RIFs: 45   (req: <= 3)

Antibodies: 831   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 158.46   (req: >= 5)

Gene RIFs: 45   (req: > 3)

Antibodies: 831   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0