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Tbio
MCM3
DNA replication licensing factor MCM3

Protein Summary
Description
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229854
  • ENSP00000229854
  • ENSG00000112118
  • ENST00000596288
  • ENSP00000472940
  • ENST00000616552
  • ENSP00000480987

Symbol
  • HCC5
  • P1.h
  • RLFB
  • P1-MCM3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
co-expressed gene
0.99
kinase perturbation
0.96
disease perturbation
0.95
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.16   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.16   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (370)
MCMBP
Tbio
Novelty:  0.13330215
p_int:  0.999999726
p_ni:  2.74e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
TSNAX
Tbio
Novelty:  0.00888891
p_int:  0.999963069
p_ni:  0.000036931
Score:  0.183
Data Source:  BioPlex,STRINGDB
MCM5
Tbio
Novelty:  0.00716583
p_int:  0.999600545
p_ni:  0.000399455
Score:  0.999
Data Source:  BioPlex,STRINGDB
MCM7
Tbio
Novelty:  0.0017984
p_int:  0.997932062
p_ni:  0.002067938
Score:  0.999
Data Source:  BioPlex,STRINGDB
TIMELESS
Tbio
Novelty:  0.0041528
p_int:  0.997203497
p_ni:  0.002796503
Score:  0.987
Data Source:  BioPlex,STRINGDB
MCM4
Tchem
Novelty:  0.00604311
p_int:  0.98689393
p_ni:  0.01310607
Score:  0.999
Data Source:  BioPlex,STRINGDB
YIPF3
Tbio
Novelty:  0.12021667
p_int:  0.986139558
p_ni:  0.013860442
Data Source:  BioPlex
MCM2
Tbio
Novelty:  0.00276275
p_int:  0.965239348
p_ni:  0.034760652
Score:  0.999
Data Source:  BioPlex,STRINGDB
CEP19
Tbio
Novelty:  0.20749222
p_int:  0.95518566
p_ni:  0.04481434
Data Source:  BioPlex
MCM6
Tbio
Novelty:  0.00675724
p_int:  0.944561808
p_ni:  0.055438192
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Activation of ATR in response to replication stress (R-HSA-176187)

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Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the pre-replicative complex
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the pre-replicative complex
Cell Cycle
Cell Cycle Checkpoints
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to gemcitabine
1
1
0
3.3
17.8
1
1
0
3.3
17.8
overall survival
1
1
0
3.3
17.8
mean platelet volume
1
1
1
6.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
response to gemcitabine
0
3.3
17.8
0
3.3
17.8
overall survival
0
3.3
17.8
mean platelet volume
1
6.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 3
VGNC:3458
462763
Macaque
minichromosome maintenance complex component 3
708320
Mouse
MGI:101845
17215
Rat
RGD:1305168
316273
Dog
minichromosome maintenance complex component 3
VGNC:43082
481839
Species
Name
OMA
EggNOG
Inparanoid
Chimp
minichromosome maintenance complex component 3
Macaque
minichromosome maintenance complex component 3
Mouse
Rat
Dog
minichromosome maintenance complex component 3
Publication Statistics
PubMed Score 156.16
PubMed score by year
PubTator Score 179.36
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title