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Tbio
MCF2L
Guanine nucleotide exchange factor DBS

Protein Summary
Description
Guanine nucleotide exchange factor that catalyzes guanine nucleotide exchange on RHOA and CDC42, and thereby contributes to the regulation of RHOA and CDC42 signaling pathways (By similarity). Seems to lack activity with RAC1. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 (PubMed:15157669). Isoform 3: Does not catalyze guanine nucleotide exchange on CDC42 (PubMed:15157669). This gene encodes a guanine nucleotide exchange factor that interacts specifically with the GTP-bound Rac1 and plays a role in the Rho/Rac signaling pathways. A variant in this gene was associated with osteoarthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375597
  • ENSP00000364747
  • ENSG00000126217
  • ENST00000375604
  • ENSP00000364754
  • ENST00000375608
  • ENSP00000364758
  • ENST00000397030
  • ENSP00000380225
  • ENST00000421756
  • ENSP00000397285
  • ENST00000535094
  • ENSP00000440374

Symbol
  • KIAA0362
  • OST
  • DBS
  • OST
  • ARHGEF14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
disease perturbation
0.83
virus perturbation
0.83
transcription factor
0.66
tissue sample
0.62


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.31   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (58)
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.989
Data Source:  STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.961
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.956
Data Source:  STRINGDB
RHOG
Tbio
Family:  Enzyme
Novelty:  0.00412327
Score:  0.952
Data Source:  STRINGDB
RAC3
Tbio
Family:  Enzyme
Novelty:  0.02125361
Score:  0.931
Data Source:  STRINGDB
RAC2
Tbio
Family:  Enzyme
Novelty:  0.00116234
Score:  0.931
Data Source:  STRINGDB
RHOB
Tbio
Family:  Enzyme
Novelty:  0.0019205
Score:  0.929
Data Source:  STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
Score:  0.929
Data Source:  STRINGDB
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
Score:  0.925
Data Source:  STRINGDB
RHOBTB2
Tbio
Novelty:  0.00734789
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Cell death signalling via NRAGE, NRIF and NADE (R-HSA-204998)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Death Receptor Signalling
Reactome
G alpha (12/13) signalling events
Reactome
GPCR downstream signalling
Reactome
NRAGE signals death through JNK
Name
Explore in Pharos
Explore in Source
Cell death signalling via NRAGE, NRIF and NADE
Death Receptor Signalling
G alpha (12/13) signalling events
GPCR downstream signalling
NRAGE signals death through JNK
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prothrombin time measurement
2
5
5
99.5
factor VII measurement
3
9
8
1.1
99.5
blood protein measurement
4
3
4
86.6
dual specificity mitogen-activated protein kinase kinase 2 measurement
1
2
2
81.6
red blood cell distribution width
2
1
2
81.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
prothrombin time measurement
5
99.5
factor VII measurement
8
1.1
99.5
blood protein measurement
4
86.6
dual specificity mitogen-activated protein kinase kinase 2 measurement
2
81.6
red blood cell distribution width
2
81.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MCF.2 cell line derived transforming sequence like
452678
Mouse
MGI:103263
17207
Rat
RGD:619782
117020
Dog
MCF.2 cell line derived transforming sequence like
VGNC:43074
485555
Horse
MCF.2 cell line derived transforming sequence like
VGNC:20028
100067048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MCF.2 cell line derived transforming sequence like
Mouse
Rat
Dog
MCF.2 cell line derived transforming sequence like
Horse
MCF.2 cell line derived transforming sequence like
Publication Statistics
PubMed Score 20.31
PubMed score by year
PubTator Score 33.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title