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Tbio
MCEE
Methylmalonyl-CoA epimerase, mitochondrial

Protein Summary
Description
The product of this gene catalyzes the interconversion of D- and L-methylmalonyl-CoA during the degradation of branched chain amino acids. odd chain-length fatty acids, and other metabolites. Mutations in this gene result in methylmalonyl-CoA epimerase deficiency, which is presented as mild to moderate methylmalonic aciduria. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244217
  • ENSP00000244217
  • ENSG00000124370

Symbol
  • GLOD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
disease perturbation
0.9
transcription factor perturbation
0.8
tissue sample
0.72
transcription factor binding site profile
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (70)
MUT
Tbio
Family:  Enzyme
Novelty:  0.00074807
Score:  0.992
Data Source:  STRINGDB
PCCB
Tbio
Family:  Enzyme
Novelty:  0.01085161
Score:  0.982
Data Source:  STRINGDB
PCCA
Tbio
Family:  Enzyme
Novelty:  0.00515417
Score:  0.977
Data Source:  STRINGDB
ECHDC1
Tbio
Family:  Enzyme
Novelty:  0.02711265
Score:  0.96
Data Source:  STRINGDB
ACSF3
Tbio
Family:  Enzyme
Novelty:  0.04255285
Score:  0.946
Data Source:  STRINGDB
SPR
Tchem
Family:  Enzyme
Novelty:  0.02144934
Score:  0.91
Data Source:  STRINGDB
MMAA
Tbio
Novelty:  0.00965052
Score:  0.88
Data Source:  STRINGDB
MMADHC
Tbio
Novelty:  0.02299238
Score:  0.794
Data Source:  STRINGDB
GCH1
Tbio
Family:  Enzyme
Novelty:  0.0025793
Score:  0.757
Data Source:  STRINGDB
MMACHC
Tbio
Novelty:  0.00896291
Score:  0.738
Data Source:  STRINGDB
Pathways (15)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Mitochondrial Fatty Acid Beta-Oxidation
Reactome
Propionyl-CoA catabolism
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Metabolism
Metabolism of lipids
Mitochondrial Fatty Acid Beta-Oxidation
Propionyl-CoA catabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
2
2
80.5
N-acetyl-D-glucosamine kinase measurement
1
1
1
22.3
eosinophil count
3
1
3
15.1
eosinophil percentage of leukocytes
1
1
1
11.1
intelligence
1
1
0
5.6
5.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
2
80.5
N-acetyl-D-glucosamine kinase measurement
1
22.3
eosinophil count
3
15.1
eosinophil percentage of leukocytes
1
11.1
intelligence
0
5.6
5.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methylmalonyl-CoA epimerase
VGNC:298
459310
Macaque
methylmalonyl-CoA epimerase
704094
Mouse
MGI:1920974
73724
Rat
RGD:1309966
293829
Dog
methylmalonyl-CoA epimerase
VGNC:43073
479018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methylmalonyl-CoA epimerase
Macaque
methylmalonyl-CoA epimerase
Mouse
Rat
Dog
methylmalonyl-CoA epimerase
Publication Statistics
PubMed Score 56.55
PubMed score by year
PubTator Score 13.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title