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Tbio
MCC
Colorectal mutant cancer protein

Protein Summary
Description
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302475
  • ENSP00000305617
  • ENSG00000171444
  • ENST00000408903
  • ENSP00000386227

Symbol
  • MCC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.86
PubMedID
0.83
histone modification site profile
0.8
hub protein
0.79
tissue sample
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.96   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
NFKBIB
Tbio
Novelty:  0.00517222
p_int:  0.999999994
p_ni:  6e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999999984
p_ni:  1.7e-8
Data Source:  BioPlex
MAGEE1
Tbio
Novelty:  0.10759081
p_int:  0.999997228
p_ni:  0.000002772
Score:  0.187
Data Source:  BioPlex,STRINGDB
SYNC
Tbio
Novelty:  0.04605223
p_int:  0.999961119
p_ni:  0.000038848
p_wrong:  3.3e-8
Data Source:  BioPlex
CCDC83
Tdark
Novelty:  0.2258549
p_int:  0.999950455
p_ni:  0.000049154
p_wrong:  3.91e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999570008
p_ni:  0.000429988
p_wrong:  4e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
BLOC1S6
Tbio
Novelty:  0.01845286
p_int:  0.998523272
p_ni:  0.001476727
p_wrong:  1e-9
Data Source:  BioPlex
DAB2IP
Tchem
Novelty:  0.01423445
p_int:  0.994253494
p_ni:  0.005721672
p_wrong:  0.000024834
Score:  0.253
Data Source:  BioPlex,STRINGDB
CCAR2
Tbio
Novelty:  0.07397743
p_int:  0.981683907
p_ni:  0.016855828
p_wrong:  0.001460266
Score:  0.28
Data Source:  BioPlex,STRINGDB
MCCC1
Tbio
Family:  Enzyme
Novelty:  0.01234441
Score:  0.903
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
2
2
71.4
waist-hip ratio
1
1
1
42.3
lip morphology measurement
1
1
1
39.6
self reported educational attainment
1
1
1
33.1
sex hormone-binding globulin measurement
2
1
2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
2
71.4
waist-hip ratio
1
42.3
lip morphology measurement
1
39.6
self reported educational attainment
1
33.1
sex hormone-binding globulin measurement
2
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MCC, WNT signaling pathway regulator
VGNC:9065
462002
Macaque
mutated in colorectal cancers
694270
Mouse
MGI:96930
328949
Dog
MCC, WNT signaling pathway regulator
VGNC:54780
611208
Horse
MCC, WNT signaling pathway regulator
VGNC:54776
100064404
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MCC, WNT signaling pathway regulator
Macaque
mutated in colorectal cancers
Mouse
Dog
MCC, WNT signaling pathway regulator
Horse
MCC, WNT signaling pathway regulator
Publication Statistics
PubMed Score 9.96
PubMed score by year
PubTator Score 48.77
PubTator score by year
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Related Publications
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PMID
Year
Title