MCAM
Cell surface glycoprotein MUC18
Protein Summary
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
- ENST00000264036
- ENSP00000264036
- ENSG00000076706
- MUC18
- CD146
- MUC18
- HEMCAM
- METCAM
- MelCAM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.99 | ||
PubMedID | 0.98 | ||
transcription factor perturbation | 0.98 | ||
disease perturbation | 0.96 | ||
disease | 0.95 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1005.41 (req: < 5)
Gene RIFs: 180 (req: <= 3)
Antibodies: 1686 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1005.41 (req: >= 5)
Gene RIFs: 180 (req: > 3)
Antibodies: 1686 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0