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Tclin
MC4R
Melanocortin receptor 4

Protein Summary
Description
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299766
  • ENSP00000299766
  • ENSG00000166603
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.79
molecular function
0.73
protein domain
0.73
disease
0.71
biological term
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1250   (req: < 5)
Gene RIFs: 286   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1250   (req: >= 5)
Gene RIFs: 286   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1308
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (1308)
CHEMBL4128926
Rendered image for CHEMBL4128926
CHEMBL2070245
Rendered image for CHEMBL2070245
CHEMBL2070251
Rendered image for CHEMBL2070251
CHEMBL2070243
Rendered image for CHEMBL2070243
CHEMBL4093140
Rendered image for CHEMBL4093140
CHEMBL3601428
Rendered image for CHEMBL3601428
CHEMBL3600918
Rendered image for CHEMBL3600918
Protein-Protein Interactions (235)
POMC
Tbio
Novelty:  0.00002436
Score:  0.996
Data Source:  Reactome,STRINGDB
AGRP
Tbio
Novelty:  0.00147804
Score:  0.995
Data Source:  STRINGDB
CRH
Tbio
Novelty:  0.000147
Score:  0.979
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.978
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.953
Data Source:  STRINGDB
GIPR
Tchem
Family:  GPCR
Novelty:  0.00961809
Score:  0.95
Data Source:  STRINGDB
GLP1R
Tclin
Family:  GPCR
Novelty:  0.0006899
Score:  0.947
Data Source:  STRINGDB
CRHR1
Tclin
Family:  GPCR
Novelty:  0.00101773
Score:  0.941
Data Source:  STRINGDB
IAPP
Tbio
Novelty:  0.0005195
Score:  0.94
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.939
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
80.1
visceral adipose tissue measurement
1
2
2
78.5
waist-hip ratio
1
1
1
75.6
grip strength measurement
1
3
3
71.3
high density lipoprotein cholesterol measurement
3
4
4
63.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
80.1
visceral adipose tissue measurement
2
78.5
waist-hip ratio
1
75.6
grip strength measurement
3
71.3
high density lipoprotein cholesterol measurement
4
63.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
melanocortin 4 receptor
VGNC:7322
468556
Macaque
melanocortin 4 receptor
698596
Mouse
MGI:99457
17202
Rat
RGD:3057
25635
Dog
melanocortin 4 receptor
VGNC:43067
483961
Species
Name
OMA
EggNOG
Inparanoid
Chimp
melanocortin 4 receptor
Macaque
melanocortin 4 receptor
Mouse
Rat
Dog
melanocortin 4 receptor
Publication Statistics
PubMed Score 1250.00
PubMed score by year
PubTator Score 712.16
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title