You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MBTD1
MBT domain-containing protein 1

Protein Summary
Description
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated 'Lys-20' on histone H4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376381
  • ENSP00000365561
  • ENSG00000011258
  • ENST00000405860
  • ENSP00000386072
  • ENST00000415868
  • ENSP00000403946
  • ENST00000586178
  • ENSP00000468304

Symbol
  • SA49P01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.84
virus perturbation
0.79
transcription factor binding site profile
0.75
small molecule perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.35   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.35   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
EPC2
Tbio
Novelty:  0.02760809
p_int:  0.999998372
p_ni:  0.000001626
p_wrong:  2e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999998213
p_ni:  0.000001787
Score:  0.331
Data Source:  BioPlex,STRINGDB
MRGBP
Tbio
Novelty:  0.09537142
p_int:  0.999995426
p_ni:  0.000004574
Score:  0.878
Data Source:  BioPlex,STRINGDB
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999993452
p_ni:  0.000006548
Score:  0.687
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999991195
p_ni:  0.000008805
Score:  0.753
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.99998935
p_ni:  0.00001065
Score:  0.826
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.99998802
p_ni:  0.00001198
Score:  0.299
Data Source:  BioPlex,STRINGDB
PLAC1
Tbio
Novelty:  0.01213036
p_int:  0.999982734
p_ni:  0.000017266
Score:  0.745
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999982538
p_ni:  0.000017462
Score:  0.688
Data Source:  BioPlex,STRINGDB
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.999979832
p_ni:  0.000020168
Score:  0.849
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
17.8
heel bone mineral density
1
1
1
17.6
1
1
1
15.8
BMI-adjusted hip circumference
1
1
1
4.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
17.8
heel bone mineral density
1
17.6
1
15.8
BMI-adjusted hip circumference
1
4.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2143977
103537
Rat
RGD:1592427
688133
Dog
mbt domain containing 1
VGNC:43063
491087
Horse
mbt domain containing 1
VGNC:20017
100070259
Cow
mbt domain containing 1
VGNC:31290
511415
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
mbt domain containing 1
Horse
mbt domain containing 1
Cow
mbt domain containing 1
Publication Statistics
PubMed Score 9.35
PubMed score by year
PubTator Score 3.30
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title