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Tbio
MBP
Myelin basic protein

Protein Summary
Description
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355994
  • ENSP00000348273
  • ENSG00000197971
  • ENST00000359645
  • ENSP00000352667
  • ENST00000382582
  • ENSP00000372025
  • ENST00000397860
  • ENSP00000380958
  • ENST00000397863
  • ENSP00000380961
  • ENST00000397865
  • ENSP00000380963
  • ENST00000397866
  • ENSP00000380964
  • ENST00000580402
  • ENSP00000462223
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phosphatase
1
transcription factor perturbation
0.99
hub protein
0.97
PubMedID
0.97
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6413.96   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 1187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6413.96   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 1187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (239)
CTDSPL
Tbio
Family:  Enzyme
Novelty:  0.00471423
p_int:  0.999772849
p_ni:  0.000227111
p_wrong:  3.9e-8
Score:  0.933
Data Source:  BioPlex,STRINGDB
CTDSP1
Tchem
Family:  Enzyme
Novelty:  0.0231786
p_int:  0.999740521
p_ni:  0.00023558
p_wrong:  0.000023899
Score:  0.812
Data Source:  BioPlex,STRINGDB
NLN
Tbio
Family:  Enzyme
Novelty:  0.01217367
p_int:  0.973146809
p_ni:  0.026853139
p_wrong:  5.3e-8
Score:  0.282
Data Source:  BioPlex,STRINGDB
IDE
Tchem
Family:  Enzyme
Novelty:  0.00207793
p_int:  0.893052127
p_ni:  0.106947873
Score:  0.287
Data Source:  BioPlex,STRINGDB
MAG
Tchem
Novelty:  0.00085621
Score:  0.944
Data Source:  STRINGDB
PLP1
Tbio
Novelty:  0.00129083
Score:  0.915
Data Source:  STRINGDB
MOG
Tbio
Novelty:  0.00048664
Score:  0.907
Data Source:  STRINGDB
MOK
Tbio
Family:  Kinase
Novelty:  0.0116106
Score:  0.901
Data Source:  STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.848
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.844
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Spinal Cord Injury
WikiPathways
Glial Cell Differentiation
WikiPathways
MECP2 and Associated Rett Syndrome
WikiPathways
Neural Crest Differentiation
WikiPathways
Structural Pathway of Interleukin 1 (IL-1)
Name
Explore in Pharos
Explore in Source
Spinal Cord Injury
Glial Cell Differentiation
MECP2 and Associated Rett Syndrome
Neural Crest Differentiation
Structural Pathway of Interleukin 1 (IL-1)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myelin basic protein
VGNC:5183
455522
Macaque
myelin basic protein
710350
Mouse
MGI:96925
17196
Rat
RGD:3054
24547
Dog
myelin basic protein
VGNC:53736
476160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myelin basic protein
Macaque
myelin basic protein
Mouse
Rat
Dog
myelin basic protein
Publication Statistics
PubMed Score 6413.96
PubMed score by year
PubTator Score 4452.05
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title