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Tbio
MBOAT7
Lysophospholipid acyltransferase 7

Protein Summary
Description
Acyltransferase which contributes to the regulation of free arachidonic acid (AA) in the cell through the remodeling of phospholipids. Mediates the conversion of lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) into phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) (LPIAT activity). Prefers arachidonoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Required for cortical lamination during brain development (By similarity). This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative spli ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245615
  • ENSP00000245615
  • ENSG00000125505
  • ENST00000338624
  • ENSP00000344377
  • ENST00000391754
  • ENSP00000375634
  • ENST00000431666
  • ENSP00000410503
  • ENST00000610862
  • ENSP00000481119
  • ENSG00000276935
  • ENST00000611239
  • ENSP00000481947
  • ENSG00000277025
  • ENST00000611602
  • ENSP00000482369
  • ENSG00000278322
  • ENST00000612053
  • ENSP00000482884
  • ENSG00000278519
  • ENST00000612567
  • ENSP00000483526
  • ENSG00000277733
  • ENST00000613506
  • ENSP00000478965
  • ENSG00000274194
  • ENST00000613746
  • ENSP00000484933
  • ENSG00000275118
  • ENST00000614279
  • ENSP00000480894
  • ENST00000615282
  • ENSP00000483987
  • ENST00000615453
  • ENSP00000482625
  • ENST00000617012
  • ENSP00000484199
  • ENST00000617656
  • ENSP00000481864
  • ENST00000617772
  • ENSP00000480575
  • ENST00000618378
  • ENSP00000482252
  • ENST00000618826
  • ENSP00000483839
  • ENSG00000277923
  • ENST00000618899
  • ENSP00000480531
  • ENSG00000273592
  • ENST00000619670
  • ENSP00000479750
  • ENST00000619745
  • ENSP00000481544
  • ENST00000619842
  • ENSP00000481455
  • ENST00000619855
  • ENSP00000484954
  • ENST00000620311
  • ENSP00000478522
  • ENST00000620371
  • ENSP00000479760
  • ENST00000620636
  • ENSP00000482742
  • ENST00000621146
  • ENSP00000481758
  • ENST00000621455
  • ENSP00000477891
  • ENST00000621612
  • ENSP00000478088
  • ENST00000621875
  • ENSP00000478041

Symbol
  • BB1
  • LENG4
  • OACT7
  • BB1
  • LRC4
  • LENG4
  • LPIAT
  • LPLAT
  • MBOA7
  • MRT57
  • OACT7
  • hMBOA-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
transcription factor perturbation
0.84
histone modification site profile
0.69
transcription factor
0.66
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.31   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.31   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (97)
SLC22A9
Tbio
Family:  Transporter
Novelty:  0.02212992
p_int:  0.990796229
p_ni:  0.009202668
p_wrong:  0.000001103
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.975500115
p_ni:  0.024498154
p_wrong:  0.000001732
Data Source:  BioPlex
COX4I1
Tbio
Family:  Enzyme
Novelty:  0.00208873
p_int:  0.974076313
p_ni:  0.025923657
p_wrong:  2.9e-8
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.938112364
p_ni:  0.061744266
p_wrong:  0.00014337
Data Source:  BioPlex
CD36
Tbio
Novelty:  0.00140825
p_int:  0.935964478
p_ni:  0.064035522
Score:  0.199
Data Source:  BioPlex,STRINGDB
SLC39A12
Tbio
Family:  Transporter
Novelty:  0.09127395
p_int:  0.932187236
p_ni:  0.067709332
p_wrong:  0.000103432
Score:  0.217
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.923027279
p_ni:  0.0769242
p_wrong:  0.000048521
Data Source:  BioPlex
TM2D2
Tdark
Novelty:  0.10390283
p_int:  0.921804911
p_ni:  0.078101739
p_wrong:  0.00009335
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.906106638
p_ni:  0.09383585
p_wrong:  0.000057511
Data Source:  BioPlex
PTGFR
Tclin
Family:  GPCR
Novelty:  0.00560908
p_int:  0.886129117
p_ni:  0.113583176
p_wrong:  0.000287706
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Acyl chain remodelling of PI (R-HSA-1482922)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PI
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PI
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (910)
Items per page:
1 – 5 of 910
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
5
5
9
98.4
creatine kinase measurement
5
5
9
98.4
creatine kinase measurement
5
5
9
98.4
creatine kinase measurement
5
5
9
98.4
creatine kinase measurement
5
5
9
98.4
Items per page:
1 – 5 of 910
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
9
98.4
creatine kinase measurement
9
98.4
creatine kinase measurement
9
98.4
creatine kinase measurement
9
98.4
creatine kinase measurement
9
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1924832
77582
Dog
membrane bound O-acyltransferase domain containing 7
VGNC:43062
100683790
Horse
membrane bound O-acyltransferase domain containing 7
VGNC:51050
100052743
Cow
membrane bound O-acyltransferase domain containing 7
VGNC:31289
504236
Pig
membrane bound O-acyltransferase domain containing 7
100521498
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
membrane bound O-acyltransferase domain containing 7
Horse
membrane bound O-acyltransferase domain containing 7
Cow
membrane bound O-acyltransferase domain containing 7
Pig
membrane bound O-acyltransferase domain containing 7
Publication Statistics
PubMed Score 74.31
PubMed score by year
PubTator Score 14.66
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title