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Tbio
MBOAT2
Lysophospholipid acyltransferase 2

Protein Summary
Description
Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305997
  • ENSP00000302177
  • ENSG00000143797

Symbol
  • OACT2
  • LPAAT
  • LPEAT
  • OACT2
  • LPCAT4
  • LPLAT 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.96
histone modification site profile
0.79
cell type or tissue
0.75
kinase perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.93   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.93   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (128)
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.999868578
p_ni:  0.000009928
p_wrong:  0.000121494
Data Source:  BioPlex
AGPAT1
Tbio
Family:  Enzyme
Novelty:  0.05245441
Score:  0.978
Data Source:  STRINGDB
GPAT4
Tbio
Family:  Enzyme
Novelty:  0.03409111
Score:  0.975
Data Source:  STRINGDB
PISD
Tbio
Family:  Enzyme
Novelty:  0.00966227
Score:  0.972
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.964
Data Source:  STRINGDB
GPAT3
Tbio
Family:  Enzyme
Novelty:  0.03251979
Score:  0.962
Data Source:  STRINGDB
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.961
Data Source:  STRINGDB
GPAM
Tbio
Family:  Enzyme
Novelty:  0.00973127
Score:  0.959
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.959
Data Source:  STRINGDB
GPAT2
Tbio
Family:  Enzyme
Novelty:  0.03807198
Score:  0.955
Data Source:  STRINGDB
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
LIPF
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PNLIP
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (13)
Acyl chain remodelling of PC (R-HSA-1482788)

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Find Similar Targets
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1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
1
1
71.3
skin aging measurement
1
1
1
6.8
sleep duration
1
1
1
0.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
71.3
skin aging measurement
1
6.8
sleep duration
1
0.1
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane bound O-acyltransferase domain containing 2
VGNC:10742
459013
Macaque
membrane bound O-acyltransferase domain containing 2
693653
Mouse
MGI:1914466
67216
Rat
RGD:1305798
313997
Dog
membrane bound O-acyltransferase domain containing 2
VGNC:49809
475658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane bound O-acyltransferase domain containing 2
Macaque
membrane bound O-acyltransferase domain containing 2
Mouse
Rat
Dog
membrane bound O-acyltransferase domain containing 2
Publication Statistics
PubMed Score 48.93
PubMed score by year
PubTator Score 28.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title