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Tbio
MBNL3
Muscleblind-like protein 3

Protein Summary
Description
Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370839
  • ENSP00000359876
  • ENSG00000076770
  • ENST00000370844
  • ENSP00000359881
  • ENST00000370849
  • ENSP00000359886
  • ENST00000370853
  • ENSP00000359890
  • ENST00000394311
  • ENSP00000377848
  • ENST00000538204
  • ENSP00000439618

Symbol
  • CHCR
  • MBLX39
  • MBXL
  • CHCR
  • MBLX
  • MBXL
  • MBLX39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
microRNA
0.74
small molecule perturbation
0.74
tissue sample
0.73
histone modification site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.76   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.76   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (42)
MBNL1
Tbio
Novelty:  0.00441241
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.398
Data Source:  BioPlex,STRINGDB
CPNE5
Tbio
Novelty:  0.09416684
p_int:  0.999582295
p_ni:  0.000374283
p_wrong:  0.000043422
Score:  0.187
Data Source:  BioPlex,STRINGDB
CNBP
Tbio
Novelty:  0.00404247
Score:  0.809
Data Source:  STRINGDB
CCT3
Tbio
Novelty:  0.01642521
Score:  0.789
Data Source:  STRINGDB
CELF1
Tbio
Novelty:  0.00666261
Score:  0.786
Data Source:  STRINGDB
CELF2
Tbio
Novelty:  0.01415365
Score:  0.76
Data Source:  STRINGDB
STK26
Tchem
Family:  Kinase
Novelty:  0.03633178
Score:  0.725
Data Source:  STRINGDB
CELF5
Tbio
Novelty:  0.04733002
Score:  0.686
Data Source:  STRINGDB
CELF4
Tbio
Novelty:  0.02895323
Score:  0.685
Data Source:  STRINGDB
AOC1
Tchem
Family:  Enzyme
Novelty:  0.00146464
Score:  0.65
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
muscleblind like splicing regulator 3
VGNC:14701
741399
Macaque
muscleblind like splicing regulator 3
706102
Mouse
MGI:2444912
171170
Rat
RGD:1565834
302492
Dog
muscleblind like splicing regulator 3
VGNC:43059
481055
Species
Name
OMA
EggNOG
Inparanoid
Chimp
muscleblind like splicing regulator 3
Macaque
muscleblind like splicing regulator 3
Mouse
Rat
Dog
muscleblind like splicing regulator 3
Publication Statistics
PubMed Score 25.76
PubMed score by year
PubTator Score 13.75
PubTator score by year
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Related Publications
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PMID
Year
Title