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Tbio
MBL2
Mannose-binding protein C

Protein Summary
Description
Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373968
  • ENSP00000363079
  • ENSG00000165471

Symbol
  • COLEC1
  • MBL
  • MBL
  • MBP
  • MBP1
  • MBPD
  • MBL2D
  • MBP-C
  • COLEC1
  • HSMBPC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
disease
0.77
gene perturbation
0.76
protein domain
0.73
cell type or tissue
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 673.21   (req: < 5)
Gene RIFs: 523   (req: <= 3)
Antibodies: 680   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 673.21   (req: >= 5)
Gene RIFs: 523   (req: > 3)
Antibodies: 680   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
TRMU
Tbio
Family:  Enzyme
Novelty:  0.01615197
p_int:  0.999999821
p_ni:  8.2e-8
p_wrong:  9.7e-8
Data Source:  BioPlex
FCN2
Tbio
Novelty:  0.00519137
Score:  0.994
Data Source:  STRINGDB
MASP1
Tchem
Family:  Enzyme
Novelty:  0.0029019
Score:  0.99
Data Source:  Reactome,STRINGDB
MASP2
Tchem
Family:  Enzyme
Novelty:  0.00466852
Score:  0.99
Data Source:  Reactome,STRINGDB
FCN3
Tbio
Novelty:  0.00771958
Score:  0.988
Data Source:  STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.97
Data Source:  Reactome,STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.97
Data Source:  Reactome,STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.955
Data Source:  Reactome,STRINGDB
FCN1
Tbio
Novelty:  0.01037775
Score:  0.938
Data Source:  STRINGDB
COLEC11
Tbio
Novelty:  0.02989413
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (63)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Immune System
Reactome
Initial triggering of complement
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Complement cascade
Creation of C4 and C2 activators
Immune System
Initial triggering of complement
Innate Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
6
12
99.3
2
2
1
1.1
93.5
bone density
2
2
2
66.6
velocity of sound measurement
1
1
1
63.4
bone quantitative ultrasound measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
12
99.3
1
1.1
93.5
bone density
2
66.6
velocity of sound measurement
1
63.4
bone quantitative ultrasound measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mannose binding lectin 2
VGNC:7240
449582
Mouse
MGI:96924
17195
Horse
mannose binding lectin 2
VGNC:20011
100034103
Cow
mannose binding lectin 2
VGNC:31280
281297
Platypus
mannose binding lectin 2
100075895
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mannose binding lectin 2
Mouse
Horse
mannose binding lectin 2
Cow
mannose binding lectin 2
Platypus
mannose binding lectin 2
Publication Statistics
PubMed Score 673.21
PubMed score by year
PubTator Score 1501.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title