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Tbio
MBIP
MAP3K12-binding inhibitory protein 1

Protein Summary
Description
Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318473
  • ENSP00000324444
  • ENSG00000151332
  • ENST00000359527
  • ENSP00000352517
  • ENST00000416007
  • ENSP00000399718
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.7
histone modification site profile
0.7
biological process
0.67
tissue
0.63
tissue sample
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.28   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (101)
TADA3
Tbio
Novelty:  0.01743814
p_int:  1
Score:  0.988
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999999992
p_ni:  8e-9
Score:  0.98
Data Source:  BioPlex,STRINGDB
TADA2A
Tbio
Family:  TF
Novelty:  0.07665459
p_int:  0.999999981
p_ni:  1.9e-8
Score:  0.988
Data Source:  BioPlex,STRINGDB
WDR5
Tchem
Novelty:  0.0059945
p_int:  0.999999966
p_ni:  3.4e-8
Score:  0.974
Data Source:  BioPlex,STRINGDB
KAT14
Tbio
Novelty:  0.17168043
p_int:  0.99999995
p_ni:  5e-8
Score:  0.98
Data Source:  BioPlex,STRINGDB
KAT2B
Tchem
Family:  Epigenetic
Novelty:  0.00172126
p_int:  0.999999832
p_ni:  1.68e-7
Score:  0.984
Data Source:  BioPlex,STRINGDB
ZZZ3
Tdark
Family:  TF
Novelty:  0.23862921
p_int:  0.999999709
p_ni:  2.91e-7
Score:  0.982
Data Source:  BioPlex,STRINGDB
ZNF131
Tbio
Family:  TF
Novelty:  0.18894578
p_int:  0.999999225
p_ni:  2.98e-7
p_wrong:  4.77e-7
Score:  0.169
Data Source:  BioPlex,STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
p_int:  0.999999183
p_ni:  8.17e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
KAT2A
Tchem
Family:  Epigenetic
Novelty:  0.00238831
p_int:  0.999997358
p_ni:  0.000002623
p_wrong:  1.9e-8
Score:  0.986
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
2
1
0
1.9
14.2
thyroid stimulating hormone measurement
1
1
1
8.3
self reported educational attainment
1
1
1
1.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
0
1.9
14.2
thyroid stimulating hormone measurement
1
8.3
self reported educational attainment
1
1.9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAP3K12 binding inhibitory protein 1
VGNC:3385
467432
Macaque
MAP3K12 binding inhibitory protein 1
696526
Mouse
MGI:1918320
217588
Rat
RGD:1306310
362740
Dog
MAP3K12 binding inhibitory protein 1
VGNC:43055
480293
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAP3K12 binding inhibitory protein 1
Macaque
MAP3K12 binding inhibitory protein 1
Mouse
Rat
Dog
MAP3K12 binding inhibitory protein 1
Publication Statistics
PubMed Score 17.28
PubMed score by year
PubTator Score 4.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title