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Tbio
MBD3L1
Methyl-CpG-binding domain protein 3-like 1

Protein Summary
Description
Transcriptional repressor. This gene encodes a protein that is related to methyl-CpG-binding proteins but lacks the methyl-CpG binding domain. The protein is localized to discrete areas in the nucleus, and expression appears to be restricted to round spermatids, suggesting that the protein plays a role in the postmeiotic stages of male germ cell development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305625
  • ENSP00000304198
  • ENSG00000170948
  • ENST00000595891
  • ENSP00000471575

Symbol
  • MBD3L
  • MBD3L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.54
kinase perturbation
0.54
cell type or tissue
0.46
cell line
0.45
cellular component
0.44


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999866
p_ni:  1.33e-7
p_wrong:  1e-9
Score:  0.828
Data Source:  BioPlex,STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999999848
p_ni:  1.52e-7
Score:  0.87
Data Source:  BioPlex,STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
p_int:  0.999999841
p_ni:  1.59e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
GATAD2A
Tbio
Novelty:  0.05599551
p_int:  0.999999596
p_ni:  4.04e-7
Score:  0.92
Data Source:  BioPlex,STRINGDB
ZNF296
Tbio
Family:  TF
Novelty:  0.25752975
p_int:  0.999999278
p_ni:  4.7e-7
p_wrong:  2.52e-7
Score:  0.465
Data Source:  BioPlex,STRINGDB
BCL11A
Tbio
Family:  TF
Novelty:  0.00456607
p_int:  0.999999202
p_ni:  7.98e-7
Score:  0.834
Data Source:  BioPlex,STRINGDB
BEND7
Tdark
Novelty:  0.5500966
p_int:  0.999998814
p_ni:  0.000001186
Score:  0.677
Data Source:  BioPlex,STRINGDB
MTA1
Tbio
Family:  TF
Novelty:  0.00464618
p_int:  0.999996856
p_ni:  0.000003144
Score:  0.885
Data Source:  BioPlex,STRINGDB
CHD4
Tchem
Family:  Epigenetic
Novelty:  0.00826969
p_int:  0.999996539
p_ni:  0.000003461
Score:  0.865
Data Source:  BioPlex,STRINGDB
CDK2AP1
Tbio
Family:  Enzyme
Novelty:  0.01584718
p_int:  0.999993169
p_ni:  0.000006812
p_wrong:  1.8e-8
Score:  0.874
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cancer antigen 125 measurement
1
68.6
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 3 like 1
VGNC:8729
468705
Macaque
methyl-CpG binding domain protein 3 like 1
708503
Mouse
MGI:1920753
73503
Rat
RGD:1308259
300389
Dog
methyl-CpG binding domain protein 3 like 1
VGNC:43051
100686483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methyl-CpG binding domain protein 3 like 1
Macaque
methyl-CpG binding domain protein 3 like 1
Mouse
Rat
Dog
methyl-CpG binding domain protein 3 like 1
Publication Statistics
PubMed Score 11.25
PubMed score by year
PubTator Score 6.20
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title