Tbio MBD1 Methyl-CpG-binding domain protein 1

Protein Summary

Description

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters. The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Feb 2011]

Uniprot Accession IDs

• Q9UIS9
• A4UTZ0
• B4DXJ5
• E9PEC5
• K7ELI2
• K7EQZ4
• K7ESN0
• O15248
• O95241
• Q7Z7B5
• Q8N4W4
• Q9UNZ6
• Q9UNZ7
• Q9UNZ8
• Q9UNZ9

Gene Name

• MBD1

Ensembl ID

• ENST00000269468
• ENSP00000269468
• ENSG00000141644
• ENST00000269471
• ENSP00000269471
• ENST00000339998
• ENSP00000339546
• ENST00000347968
• ENSP00000285102
• ENST00000353909
• ENSP00000269469
• ENST00000382948
• ENSP00000372407
• ENST00000398488
• ENSP00000381502
• ENST00000398493
• ENSP00000381506
• ENST00000457839
• ENSP00000405268
• ENST00000585595
• ENSP00000468430
• ENST00000585672
• ENSP00000466092
• ENST00000587605
• ENSP00000468042
• ENST00000588937
• ENSP00000467763
• ENST00000590208
• ENSP00000468785
• ENST00000591416
• ENSP00000467017
• ENST00000591535
• ENSP00000465923

Symbol

• CXXC3
• PCM1
• RFT
• PCM1
• CXXC3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
transcription factor perturbation	0.91
disease perturbation	0.79
molecular function	0.79
microRNA	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.92   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 372   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.92   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 372   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0