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Tbio
MB
Myoglobin

Protein Summary
Description
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. This gene encodes a member of the globin superfamily and is expressed in skeletal and cardiac muscles. The encoded protein is a haemoprotein contributing to intracellular oxygen storage and transcellular facilitated diffusion of oxygen. At least three alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359787
  • ENSP00000352835
  • ENSG00000198125
  • ENST00000397326
  • ENSP00000380489
  • ENST00000397328
  • ENSP00000380491
  • ENST00000406324
  • ENSP00000384239

Symbol
  • PVALB
  • myoglobgin
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.68
small molecule perturbation
0.67
PubMedID
0.66
transcription factor
0.63
biological term
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13023.35   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 1217   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13023.35   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 1217   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (145)
ANK1
Tbio
Novelty:  0.00225305
p_int:  0.995671066
p_ni:  0.003466394
p_wrong:  0.000862541
Score:  0.265
Data Source:  BioPlex,STRINGDB
CORT
Tbio
Novelty:  0.00789975
p_int:  0.897240724
p_ni:  0.102654758
p_wrong:  0.000104518
Score:  0.685
Data Source:  BioPlex,STRINGDB
CKMT2
Tbio
Family:  Kinase
Novelty:  0.00904745
Score:  0.878
Data Source:  STRINGDB
TG
Tbio
Novelty:  0.00010111
Score:  0.871
Data Source:  STRINGDB
NGB
Tbio
Novelty:  0.00247805
Score:  0.867
Data Source:  STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.843
Data Source:  STRINGDB
CKM
Tbio
Family:  Kinase
Novelty:  0.00239628
Score:  0.839
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.834
Data Source:  STRINGDB
TNNI3
Tbio
Novelty:  0.00020053
Score:  0.821
Data Source:  STRINGDB
MYL1
Tbio
Novelty:  0.00360262
Score:  0.797
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (32)
Intracellular oxygen transport (R-HSA-8981607)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular oxygen transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Intracellular oxygen transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
2
3
57.1
sex hormone-binding globulin measurement
3
2
3
49.9
lifestyle measurement
1
1
1
29.3
anxiety disorder measurement
1
1
1
29.3
blood protein measurement
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
57.1
sex hormone-binding globulin measurement
3
49.9
lifestyle measurement
1
29.3
anxiety disorder measurement
1
29.3
blood protein measurement
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myoglobin
VGNC:5276
740117
Macaque
myoglobin
693269
Mouse
MGI:96922
17189
Rat
RGD:620411
59108
Dog
myoglobin
VGNC:43046
608715
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myoglobin
Macaque
myoglobin
Mouse
Rat
Dog
myoglobin
Publication Statistics
PubMed Score 13023.35
PubMed score by year
PubTator Score 3639.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title