Tbio MAVS Mitochondrial antiviral-signaling protein

Protein Summary

Description

Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. This gene encodes an intermediary protein necessary in the virus-triggered beta interferon signaling pathways. It is required for activation of transcription factors which regulate expression of beta interferon and contributes to antiviral immunity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q7Z434
• A8K6X0
• B2BD33
• B2BD34
• F5H6C8
• M1P2Z0
• Q2HWT5
• Q3I0Y2
• Q5T7I6
• Q86VY7
• Q9H1H3
• Q9H4Y1
• Q9H8D3
• Q9ULE9
• MAVS

Gene Name

• MAVS

Ensembl ID

• ENST00000416600
• ENSP00000413749
• ENSG00000088888
• ENST00000428216
• ENSP00000401980

Symbol

• IPS1
• KIAA1271
• VISA
• IPS1
• VISA
• IPS-1
• CARDIF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.98
histone modification site profile	0.81
kinase perturbation	0.76
cellular component	0.75
hub protein	0.75

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.41   (req: < 5)

Gene RIFs: 191   (req: <= 3)

Antibodies: 564   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 639.41   (req: >= 5)

Gene RIFs: 191   (req: > 3)

Antibodies: 564   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0