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Tdark
MAU2
MAU2 chromatid cohesion factor homolog

Protein Summary
Description
Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262815
  • ENSP00000262815
  • ENSG00000129933

Symbol
  • KIAA0892
  • SCC4
  • SCC4
  • MAU2L
  • mau-2
  • KIAA0892
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
transcription factor perturbation
0.84
transcription factor binding site profile
0.81
disease perturbation
0.74
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.21   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 42   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 149.21   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
GPSM3
Tbio
Novelty:  0.01632501
p_int:  0.999999891
p_ni:  1.09e-7
Data Source:  BioPlex
ARFGAP1
Tbio
Family:  Enzyme
Novelty:  0.02654081
p_int:  0.999998448
p_ni:  7.4e-7
p_wrong:  8.12e-7
Score:  0.253
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.999864229
p_ni:  0.00009853
p_wrong:  0.000037241
Data Source:  BioPlex
NMB
Tbio
Novelty:  0.00729571
p_int:  0.999806182
p_ni:  0.000079992
p_wrong:  0.000113826
Data Source:  BioPlex
MOB3C
Tdark
Family:  Enzyme
Novelty:  1.77708434
p_int:  0.963367704
p_ni:  0.002998719
p_wrong:  0.033633577
Score:  0.685
Data Source:  BioPlex,STRINGDB
NIPBL
Tbio
Novelty:  0.00462654
Score:  0.998
Data Source:  Reactome,STRINGDB
SMC3
Tbio
Novelty:  0.00474377
Score:  0.989
Data Source:  STRINGDB
WAPL
Tbio
Novelty:  0.01598061
Score:  0.986
Data Source:  Reactome,STRINGDB
RAD21
Tbio
Novelty:  0.00270936
Score:  0.985
Data Source:  STRINGDB
PDS5A
Tbio
Novelty:  0.0142948
Score:  0.985
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cohesin Loading onto Chromatin
Reactome
M Phase
Reactome
Mitotic Telophase/Cytokinesis
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cohesin Loading onto Chromatin
M Phase
Mitotic Telophase/Cytokinesis
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (58)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
14
10
19
3.8
99.7
triglyceride measurement
18
9
27
8.2
99.6
total cholesterol measurement
9
6
13
4.4
99.4
apolipoprotein B measurement
2
4
4
98.5
serum alanine aminotransferase measurement
3
4
4
17.9
98.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
19
3.8
99.7
triglyceride measurement
27
8.2
99.6
total cholesterol measurement
13
4.4
99.4
apolipoprotein B measurement
4
98.5
serum alanine aminotransferase measurement
4
17.9
98.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1921799
74549
Rat
RGD:1308759
290668
Dog
MAU2 sister chromatid cohesion factor
VGNC:43043
484807
Horse
MAU2 sister chromatid cohesion factor
VGNC:20000
100069690
Cow
MAU2 sister chromatid cohesion factor
VGNC:31267
528175
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
MAU2 sister chromatid cohesion factor
Horse
MAU2 sister chromatid cohesion factor
Cow
MAU2 sister chromatid cohesion factor
Publication Statistics
PubMed Score 149.21
PubMed score by year
PubTator Score 110.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title