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Tdark
MATN4
Matrilin-4

Protein Summary
Description
Major component of the extracellular matrix of cartilage. This gene encodes a member of von Willebrand factor A domain-containing protein family. The proteins of this family are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This family member is thought to be play a role in reorganizing and regenerating the corneal matrix in granular and lattice type I dystrophies. It may also be involved in wound healing in the dentin-pulp complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360607
  • ENSP00000353819
  • ENSG00000124159
  • ENST00000372754
  • ENSP00000361840
  • ENST00000372756
  • ENSP00000361842
  • ENST00000537548
  • ENSP00000440328
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
gene perturbation
0.64
virus perturbation
0.59
interacting protein
0.58
PubMedID
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
VIPAS39
Tbio
Novelty:  0.02348642
p_int:  0.999999893
p_ni:  1.05e-7
p_wrong:  2e-9
Score:  0.222
Data Source:  BioPlex,STRINGDB
VPS33B
Tbio
Novelty:  0.02221093
p_int:  0.999999864
p_ni:  1.34e-7
p_wrong:  2e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
CILP2
Tbio
Novelty:  0.07992715
p_int:  0.999991892
p_ni:  0.000008086
p_wrong:  2.2e-8
Score:  0.28
Data Source:  BioPlex,STRINGDB
MATN1
Tbio
Novelty:  0.00337153
p_int:  0.999980761
p_wrong:  0.000019239
Score:  0.638
Data Source:  BioPlex,STRINGDB
GMEB1
Tbio
Family:  TF
Novelty:  0.10522678
p_int:  0.998294413
p_ni:  0.001705586
Score:  0.188
Data Source:  BioPlex,STRINGDB
NACC1
Tbio
Novelty:  0.03367769
p_int:  0.997978588
p_ni:  0.000683636
p_wrong:  0.001337777
Score:  0.23
Data Source:  BioPlex,STRINGDB
BCS1L
Tbio
Family:  Enzyme
Novelty:  0.01764582
p_int:  0.997601089
p_ni:  0.002398808
p_wrong:  1.04e-7
Data Source:  BioPlex
ARG2
Tchem
Family:  Enzyme
Novelty:  0.0006655
p_int:  0.993810137
p_ni:  0.006189863
Score:  0.306
Data Source:  BioPlex,STRINGDB
ZMYM2
Tbio
Novelty:  0.0258698
p_int:  0.963090675
p_ni:  0.036909325
Score:  0.165
Data Source:  BioPlex,STRINGDB
COMP
Tbio
Novelty:  0.00139358
Score:  0.966
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
72.5
elafin measurement
1
1
1
10.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
72.5
elafin measurement
1
10.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrilin 4
VGNC:52086
458279
Mouse
MGI:1328314
17183
Rat
RGD:1309732
296358
Dog
matrilin 4
VGNC:43042
485891
Horse
matrilin 4
VGNC:19999
100070904
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrilin 4
Mouse
Rat
Dog
matrilin 4
Horse
matrilin 4
Publication Statistics
PubMed Score 4.00
PubMed score by year
PubTator Score 10.73
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title