Protein Summary
Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
- ENST00000407540
- ENSP00000383894
- ENSG00000132031
- ENST00000421259
- ENSP00000398753
- HOA
- OS2
- EDM5
- DIPOA
- OADIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.81 | ||
protein domain | 0.73 | ||
PubMedID | 0.73 | ||
transcription factor perturbation | 0.61 | ||
tissue sample | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.73 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 206 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 247.73 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 206 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (161)
TF
Novelty: 0.00231826
p_int: 0.977789847
p_ni: 0.022210153
Score: 0.922
Data Source: BioPlex,STRINGDB
PBLD
Novelty: 0.09777309
p_int: 0.920409261
p_ni: 0.079590739
Score: 0.455
Data Source: BioPlex,STRINGDB
GDA
Family: Enzyme
Novelty: 0.01846276
p_int: 0.820741467
p_ni: 0.179258533
Score: 0.379
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
Reactome (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | ECM proteoglycans | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Post-translational protein modification | ||||
Reactome | Post-translational protein phosphorylation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
ECM proteoglycans | ||||
Extracellular matrix organization | ||||
Metabolism of proteins | ||||
Post-translational protein modification | ||||
Post-translational protein phosphorylation | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (4)
Processes (5)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 2 | 2 | 57.7 | |||||
waist-hip ratio | 1 | 1 | 1 | 15.8 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 57.7 | |||||
waist-hip ratio | 1 | 15.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | matrilin 3 | VGNC:10721 | 459514 | |||||
Macaque | matrilin 3 | 716677 | ||||||
Mouse | MGI:1328350 | 17182 | ||||||
Rat | RGD:1305085 | 313954 | ||||||
Dog | matrilin 3 | VGNC:43041 | 482985 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | matrilin 3 | |||||
Macaque | matrilin 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | matrilin 3 | |||||
Publication Statistics
PubMed Score 247.73
PubMed score by year
PubTator Score 98.86
PubTator score by year
Related Publications
Text Mined References (44)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
---|