Tbio MATN3 Matrilin-3

Protein Summary

Description

Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15232
• B2CPU0
• Q4ZG02

Gene Name

• MATN3

Ensembl ID

• ENST00000407540
• ENSP00000383894
• ENSG00000132031
• ENST00000421259
• ENSP00000398753

Symbol

• HOA
• OS2
• EDM5
• DIPOA
• OADIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
protein domain	0.73
PubMedID	0.73
transcription factor perturbation	0.61
tissue sample	0.59

Protein Classes

PANTHER Classes

Protein / Receptor / Matrilin-3

DTO Classes

Protein / Receptor / Matrilin-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.73   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 206   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 247.73   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (161)

Explore Interacting Targets

1 – 10 of 161

• See Interactions on String-DB

TF

Tbio

Novelty:  0.00231826

p_int:  0.977789847

p_ni:  0.022210153

Score:  0.922

Data Source:  BioPlex,STRINGDB

PBLD

Tbio

Novelty:  0.09777309

p_int:  0.920409261

p_ni:  0.079590739

Score:  0.455

Data Source:  BioPlex,STRINGDB

GDA

Tbio

Family:  Enzyme

Novelty:  0.01846276

p_int:  0.820741467

p_ni:  0.179258533

Score:  0.379

Data Source:  BioPlex,STRINGDB

COMP

Tbio

Novelty:  0.00139358

Score:  0.983

Data Source:  STRINGDB

FN1

Tchem

Novelty:  0.00003647

Score:  0.942

Data Source:  STRINGDB

PDIA6

Tchem

Family:  Enzyme

Novelty:  0.01692178

Score:  0.932

Data Source:  STRINGDB

APOB

Tchem

Novelty:  0.00008247

Score:  0.932

Data Source:  STRINGDB

VWA1

Tbio

Novelty:  0.00212445

Score:  0.923

Data Source:  STRINGDB

HSP90B1

Tchem

Novelty:  0.00135881

Score:  0.923

Data Source:  STRINGDB

BMP4

Tchem

Novelty:  0.00047387

Score:  0.916

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (6)

ECM proteoglycans (R-HSA-3000178)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	ECM proteoglycans	56 targets	R-HSA-3000178
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	Post-translational protein phosphorylation	107 targets	R-HSA-8957275

Name	Explore in Pharos	Explore in Source
ECM proteoglycans	56 targets	R-HSA-3000178
Extracellular matrix organization	297 targets	R-HSA-1474244
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
Post-translational protein phosphorylation	107 targets	R-HSA-8957275

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (2)

Components (4)

Processes (5)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
extracellular matrix structural constituent	Traceable Author Statement (TAS)	ProtInc
calcium ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (2)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2	2	2		57.7
waist-hip ratio	EFO_0004343	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2		57.7
waist-hip ratio	EFO_0004343	1		15.8

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Coiled coil
Complete proteome
Disease mutation
Disulfide bond
Dwarfism
EGF-like domain
Methylation
Phosphoprotein
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted waist circumference
waist-hip ratio

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
growth/size/body region phenotype
immune system phenotype
limbs/digits/tail phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	matrilin 3	VGNC:10721	459514
Macaque	matrilin 3		716677
Mouse	matrilin 3	MGI:1328350	17182
Rat	matrilin 3	RGD:1305085	313954
Dog	matrilin 3	VGNC:43041	482985

Species	Name	OMA	EggNOG	Inparanoid
Chimp	matrilin 3
Macaque	matrilin 3
Mouse	matrilin 3
Rat	matrilin 3
Dog	matrilin 3

Publication Statistics

PubMed Score 247.73

PubMed score by year

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PubTator Score 98.86

PubTator score by year

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Related Publications

Text Mined References (44)

GeneRif Annotations (31)

Items per page:

10

0 of 0

PMID	Year	Title