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Tbio
MATN2
Matrilin-2

Protein Summary
Description
Involved in matrix assembly. This gene encodes a member of the von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains five von Willebrand factor A domains. The specific function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254898
  • ENSP00000254898
  • ENSG00000132561
  • ENST00000520016
  • ENSP00000430487
  • ENST00000521689
  • ENSP00000429977
  • ENST00000522025
  • ENSP00000429010
  • ENST00000524308
  • ENSP00000430221
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
protein domain
0.97
kinase perturbation
0.93
transcription factor perturbation
0.91
disease perturbation
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.58   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
COMP
Tbio
Novelty:  0.00139358
p_int:  0.999989256
p_ni:  0.000010744
Score:  0.599
Data Source:  BioPlex,STRINGDB
CORO1A
Tbio
Novelty:  0.00898925
p_int:  0.999946269
p_ni:  0.000053731
Data Source:  BioPlex
TRAF7
Tbio
Family:  Enzyme
Novelty:  0.02437761
p_int:  0.999892648
p_ni:  0.000107352
Score:  0.156
Data Source:  BioPlex,STRINGDB
NELL1
Tbio
Family:  Enzyme
Novelty:  0.01325888
p_int:  0.999846725
p_ni:  7.73e-7
p_wrong:  0.000152502
Score:  0.213
Data Source:  BioPlex,STRINGDB
NELL2
Tbio
Family:  Enzyme
Novelty:  0.03760438
p_int:  0.999811684
p_ni:  0.000181364
p_wrong:  0.000006953
Score:  0.244
Data Source:  BioPlex,STRINGDB
PXDN
Tbio
Novelty:  0.00935722
p_int:  0.999630058
p_ni:  0.000369942
Score:  0.238
Data Source:  BioPlex,STRINGDB
BANP
Tbio
Novelty:  0.02145545
p_int:  0.999349474
p_ni:  0.000650525
Data Source:  BioPlex
NID2
Tbio
Novelty:  0.01638372
p_int:  0.99924011
p_ni:  0.000759855
p_wrong:  3.5e-8
Score:  0.234
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.998904594
p_ni:  0.001095406
p_wrong:  1e-9
Data Source:  BioPlex
THBS4
Tbio
Novelty:  0.00988079
p_int:  0.99567822
p_ni:  1.2e-8
p_wrong:  0.004321768
Score:  0.294
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
matrilin 2
VGNC:13177
472939
Macaque
matrilin 2
705161
Mouse
MGI:109613
17181
Rat
RGD:1305353
299996
Dog
matrilin 2
VGNC:43040
491431
Species
Name
OMA
EggNOG
Inparanoid
Chimp
matrilin 2
Macaque
matrilin 2
Mouse
Rat
Dog
matrilin 2
Publication Statistics
PubMed Score 13.58
PubMed score by year
PubTator Score 19.82
PubTator score by year
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Related Publications
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PMID
Year
Title