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Tbio
MATN1
Cartilage matrix protein

Protein Summary
Description
Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373765
  • ENSP00000362870
  • ENSG00000162510

Symbol
  • CMP
  • CRTM
  • CMP
  • CRTM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.69
tissue sample
0.61
protein domain
0.58
microRNA
0.51
gene perturbation
0.49


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.84   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 200.84   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
MATN4
Tdark
Novelty:  0.31964843
p_int:  0.999980761
p_wrong:  0.000019239
Score:  0.638
Data Source:  BioPlex,STRINGDB
COMP
Tbio
Novelty:  0.00139358
Score:  0.969
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.767
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.694
Data Source:  STRINGDB
CHAD
Tbio
Novelty:  0.00879818
Score:  0.631
Data Source:  STRINGDB
PRG4
Tbio
Novelty:  0.00250611
Score:  0.61
Data Source:  STRINGDB
ACP1
Tchem
Family:  Enzyme
Novelty:  0.00409713
Score:  0.566
Data Source:  STRINGDB
MPP5
Tbio
Novelty:  0.01707773
Score:  0.56
Data Source:  STRINGDB
MYO1H
Tdark
Novelty:  0.13056549
Score:  0.557
Data Source:  STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
Score:  0.552
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
2
3
66.1
blood protein measurement
3
1
3
39.7
monocyte count
2
2
2
37.7
myeloid white cell count
1
1
1
28.6
neutrophil count
3
1
3
25.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
66.1
blood protein measurement
3
39.7
monocyte count
2
37.7
myeloid white cell count
1
28.6
neutrophil count
3
25.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:106591
17180
Rat
RGD:1359410
297894
Dog
matrilin 1
VGNC:52217
Horse
matrilin 1
VGNC:19996
100056375
Cow
matrilin 1
VGNC:31264
512059
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
matrilin 1
Horse
matrilin 1
Cow
matrilin 1
Publication Statistics
PubMed Score 200.84
PubMed score by year
PubTator Score 79.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title