Tbio MATK Megakaryocyte-associated tyrosine-protein kinase

Protein Summary

Description

Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation. The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P42679
• B3KNZ9
• Q9NST8

Gene Name

• MATK

Ensembl ID

• ENST00000310132
• ENSP00000308734
• ENSG00000007264
• ENST00000395040
• ENSP00000378481
• ENST00000395045
• ENSP00000378485
• ENST00000619596
• ENSP00000483213

Symbol

• CTK
• HYL
• CHK
• CTK
• HYL
• Lsk
• HYLTK
• HHYLTK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
small molecule perturbation	0.65
disease perturbation	0.56
disease	0.55

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Csk Family / Megakaryocyte-associated Tyrosine-protein Kinase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.23   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 329   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.23   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0