MAT2A
S-adenosylmethionine synthase isoform type-2
Protein Summary
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate. The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]
- ENST00000306434
- ENSP00000303147
- ENSG00000168906
- ENST00000409017
- ENSP00000386353
- AMS2
- MATA2
- MATA2
- MATII
- SAMS2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.99 | ||
transcription factor perturbation | 0.99 | ||
transcription factor binding site profile | 0.97 | ||
molecular function | 0.9 | ||
protein domain | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 218.54 (req: < 5)
Gene RIFs: 45 (req: <= 3)
Antibodies: 332 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 218.54 (req: >= 5)
Gene RIFs: 45 (req: > 3)
Antibodies: 332 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 84
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0