Tbio MARVELD2 MARVEL domain-containing protein 2

Protein Summary

Description

Plays a role in the formation of tricellular tight junctions and of epithelial barriers (By similarity). Required for normal hearing via its role in the separation of the endolymphatic and perilymphatic spaces of the organ of Corti in the inner ear, and for normal survival of hair cells in the organ of Corti (PubMed:17186462). The protein encoded by this gene is a membrane protein found at the tight junctions between epithelial cells. The encoded protein helps establish epithelial barriers such as those in the organ of Corti, where these barriers are required for normal hearing. Defects in this gene are a cause of deafness autosomal recessive type 49 (DFNB49). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• Q8N4S9
• A1BQX0
• A1BQX1
• A8KA97
• Q96NM9

Gene Name

• MARVELD2

Ensembl ID

• ENST00000325631
• ENSP00000323264
• ENSG00000152939
• ENST00000454295
• ENSP00000396244
• ENST00000614617
• ENSP00000480044
• ENSG00000274671
• ENST00000622835
• ENSP00000480068
• ENST00000645446
• ENSP00000494616
• ENST00000646733
• ENSP00000496750
• ENST00000647531
• ENSP00000493858

Symbol

• TRIC
• Tric
• DFNB49
• MARVD2
• MRVLDC2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
virus perturbation	0.85
disease perturbation	0.79
cellular component	0.75
transcription factor perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Marvel Domain-containing Protein 2

Protein / Cell Junction Protein / Tight Junction / Marvel Domain-containing Protein 2

DTO Classes

Protein / Cell-cell Junction / Tight Junction / Marvel Domain-containing Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.02   (req: < 5)

Gene RIFs: 26   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.02   (req: >= 5)

Gene RIFs: 26   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0