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Tchem
MARK2
Serine/threonine-protein kinase MARK2

Protein Summary
Description
Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000350490
  • ENSP00000294247
  • ENSG00000072518
  • ENST00000361128
  • ENSP00000355091
  • ENST00000402010
  • ENSP00000385751
  • ENST00000408948
  • ENSP00000386128
  • ENST00000508192
  • ENSP00000425765
  • ENST00000509502
  • ENSP00000423974
  • ENST00000513765
  • ENSP00000421075

Symbol
  • EMK1
  • EMK1
  • EMK-1
  • PAR-1
  • Par1b
  • Par-1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
molecular function
1
protein domain
0.97
kinase
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.65   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 418   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 204.65   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 418   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0