MARCKS
Myristoylated alanine-rich C-kinase substrate
Protein Summary
MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein. The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]
- ENST00000612661
- ENSP00000478061
- ENSG00000277443
- MACS
- PRKCSL
- MACS
- 80K-L
- PKCSL
- PRKCSL
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
ligand (protein) perturbation | 0.99 | ||
PubMedID | 0.98 | ||
interacting protein | 0.97 | ||
transcription factor binding site profile | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.26 (req: < 5)
Gene RIFs: 67 (req: <= 3)
Antibodies: 818 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 684.26 (req: >= 5)
Gene RIFs: 67 (req: > 3)
Antibodies: 818 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0