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Tbio
MARCH7
E3 ubiquitin-protein ligase MARCH7

Protein Summary
Description
E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259050
  • ENSP00000259050
  • ENSG00000136536
  • ENST00000409175
  • ENSP00000386830
  • ENST00000409591
  • ENSP00000387238

Symbol
  • AXOT
  • RNF177
  • AXO
  • AXOT
  • RNF177
  • MARCH-VII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.82
transcription factor perturbation
0.74
histone modification site profile
0.69
microRNA
0.63
disease perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.5   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (108)
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.943308445
p_ni:  0.056691555
Data Source:  BioPlex
UBXN1
Tbio
Novelty:  0.10675958
p_int:  0.940349827
p_ni:  0.059650132
p_wrong:  4.2e-8
Score:  0.225
Data Source:  BioPlex,STRINGDB
DRC3
Tdark
Novelty:  0.99283468
p_int:  0.933927804
p_ni:  0.066072189
p_wrong:  7e-9
Data Source:  BioPlex
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.931189312
p_ni:  0.068810688
Score:  0.189
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.916747348
p_ni:  0.083252641
p_wrong:  1.2e-8
Score:  0.205
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.811989569
p_ni:  0.188010431
Score:  0.241
Data Source:  BioPlex,STRINGDB
PVALB
Tbio
Novelty:  0.00024439
Score:  0.76
Data Source:  STRINGDB
HCN1
Tclin
Family:  IC
Novelty:  0.02529554
Score:  0.718
Data Source:  STRINGDB
PPP1R9A
Tbio
Novelty:  0.04851082
Score:  0.711
Data Source:  STRINGDB
NFASC
Tbio
Novelty:  0.00545331
Score:  0.679
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
5
7
7
94.6
platelet crit
2
8
8
90.4
platelet count
6
7
9
89.5
leukocyte count
3
5
5
87.6
myeloid white cell count
2
2
2
82.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
7
94.6
platelet crit
8
90.4
platelet count
9
89.5
leukocyte count
5
87.6
myeloid white cell count
2
82.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 7
VGNC:2009
459681
Macaque
membrane associated ring-CH-type finger 7
703010
Mouse
MGI:1931053
57438
Rat
RGD:1308993
311059
Dog
membrane associated ring-CH-type finger 7
VGNC:43020
478763
Species
Name
OMA
EggNOG
Inparanoid
Chimp
membrane associated ring-CH-type finger 7
Macaque
membrane associated ring-CH-type finger 7
Mouse
Rat
Dog
membrane associated ring-CH-type finger 7
Publication Statistics
PubMed Score 69.50
PubMed score by year
PubTator Score 94.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title