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Tchem
MAPT
Microtubule-associated protein tau

Protein Summary
Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262410
  • ENSP00000262410
  • ENSG00000186868
  • ENST00000334239
  • ENSP00000334886
  • ENST00000340799
  • ENSP00000340438
  • ENST00000344290
  • ENSP00000340820
  • ENST00000351559
  • ENSP00000303214
  • ENST00000415613
  • ENSP00000410838
  • ENST00000420682
  • ENSP00000413056
  • ENST00000431008
  • ENSP00000389250
  • ENST00000446361
  • ENSP00000408975
  • ENST00000535772
  • ENSP00000443028
  • ENST00000571987
  • ENSP00000458742
  • ENST00000574436
  • ENSP00000460965
  • ENST00000612872
  • ENSP00000478602
  • ENSG00000277956
  • ENST00000613360
  • ENSP00000483784
  • ENSG00000276155
  • ENST00000620070
  • ENSP00000484491
  • ENST00000620818
  • ENSP00000484321
  • ENST00000620981
  • ENSP00000481769
  • ENST00000621329
  • ENSP00000477703
  • ENST00000622106
  • ENSP00000482244
  • ENST00000622728
  • ENSP00000479142
  • ENST00000626571
  • ENSP00000486039
  • ENST00000628393
  • ENSP00000487570
  • ENST00000631447
  • ENSP00000488373
  • ENST00000632500
  • ENSP00000487837
  • ENST00000633047
  • ENSP00000488245
  • ENST00000634049
  • ENSP00000487819

Symbol
  • MAPTL
  • MTBT1
  • TAU
  • TAU
  • MSTD
  • PPND
  • DDPAC
  • MAPTL
  • MTBT1
  • MTBT2
  • FTDP-17
  • PPP1R103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
kinase
1
phosphatase
0.99
PubMedID
0.99


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7295.8   (req: < 5)
Gene RIFs: 1252   (req: <= 3)
Antibodies: 4894   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7295.8   (req: >= 5)
Gene RIFs: 1252   (req: > 3)
Antibodies: 4894   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2307
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
GWAS Traits (94)
Items per page:
1 – 5 of 94
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
2
2
0
1.9
99.1
Progressive supranuclear palsy
2
2
0
1.9
99.1
3
2
0
1.3
99
3
2
0
1.3
99
neuroticism measurement
3
9
4
7
98.8
Items per page:
1 – 5 of 94
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
0
1.9
99.1
Progressive supranuclear palsy
0
1.9
99.1
0
1.3
99
0
1.3
99
neuroticism measurement
4
7
98.8
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein tau
VGNC:12432
450177
Mouse
MGI:97180
17762
Rat
RGD:69329
29477
Dog
microtubule associated protein tau
VGNC:43012
480488
Horse
microtubule associated protein tau
VGNC:19972
100054638
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein tau
Mouse
Rat
Dog
microtubule associated protein tau
Horse
microtubule associated protein tau
Protein Structure (43 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10636-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 43
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (198)
Activation of AMPK downstream of NMDARs (R-HSA-9619483)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Name
Explore in Pharos
Explore in Source
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Gene Ontology Terms (108)
Items per page:
10
1 – 10 of 25
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (325)
1 – 10 of 325
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.999869985
p_ni: 0.000130015
Data Source: BioPlex
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.999858434
p_ni: 0.000141566
Data Source: BioPlex
DGUOK
Tbio
Family: Kinase
Novelty: 0.00897987
p_int: 0.999479429
p_ni: 0.000520571
Data Source: BioPlex
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.998919432
p_ni: 0.001080568
Data Source: BioPlex
NME2
Tbio
Family: Kinase
Novelty: 0.00257937
p_int: 0.996301526
p_ni: 0.003698413
p_wrong: 6.1e-8
Data Source: BioPlex
HSPA8
Tchem
Novelty: 0.00081014
p_int: 0.982292678
p_ni: 0.017707322
Score: 0.627
Data Source: BioPlex,STRINGDB
GNPNAT1
Tbio
Family: Enzyme
Novelty: 0.01739665
p_int: 0.963603138
p_ni: 0.007010816
p_wrong: 0.029386046
Score: 0.188
Data Source: BioPlex,STRINGDB
ARMC1
Tbio
Novelty: 0.02018109
p_int: 0.957977408
p_ni: 0.042022554
p_wrong: 3.8e-8
Score: 0.205
Data Source: BioPlex,STRINGDB
RRP7A
Tbio
Novelty: 0.11315285
p_int: 0.803988158
p_ni: 0.196011461
p_wrong: 3.81e-7
Data Source: BioPlex
CDCA8
Tbio
Novelty: 0.01448513
p_int: 0.792804027
p_ni: 0.207195973
Score: 0.186
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7295.80

PubMed score by year
PubTator Score  1481.3

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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