You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAPRE2
Microtubule-associated protein RP/EB family member 2

Protein Summary
Description
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity). The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300249
  • ENSP00000300249
  • ENSG00000166974
  • ENST00000413393
  • ENSP00000396074
  • ENST00000436190
  • ENSP00000407723
  • ENST00000538170
  • ENSP00000446343
  • ENST00000588910
  • ENSP00000468588
  • ENST00000589699
  • ENSP00000464921

Symbol
  • RP1
  • EB1
  • EB2
  • RP1
  • CSCSC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
transcription factor
0.89
trait
0.75
PubMedID
0.68
small molecule perturbation
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.36   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.36   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (125)
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.999996065
p_ni:  0.000003935
Score:  0.721
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999823803
p_ni:  0.000176197
Data Source:  BioPlex
CRTAC1
Tbio
Novelty:  0.09442374
p_int:  0.995650652
p_ni:  0.004328881
p_wrong:  0.000020467
Score:  0.787
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
p_int:  0.994192589
p_ni:  0.005807404
p_wrong:  7e-9
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.992194734
p_ni:  0.007805149
p_wrong:  1.17e-7
Data Source:  BioPlex
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.976195725
p_ni:  0.023802664
p_wrong:  0.000001612
Data Source:  BioPlex
SDF4
Tbio
Novelty:  0.00105893
p_int:  0.885703851
p_ni:  0.11427245
p_wrong:  0.000023698
Score:  0.157
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.854147339
p_ni:  0.141138418
p_wrong:  0.004714243
Data Source:  BioPlex
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.853857176
p_ni:  0.072949804
p_wrong:  0.07319302
Data Source:  BioPlex
MCM6
Tbio
Novelty:  0.00675724
Score:  0.991
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Find Similar Targets
Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
Ciliary landscape
WikiPathways
PI3K-Akt Signaling Pathway
Name
Explore in Pharos
Explore in Source
Ciliary landscape
Ciliary landscape
Ciliary landscape
Ciliary landscape
PI3K-Akt Signaling Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Brugada syndrome
1
1
0
1.3
55.6
corneal topography
1
1
1
54.9
electrocardiography
1
1
4
42.9
cortical thickness
1
1
0
6.9
42.6
educational attainment
1
1
1
29.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Brugada syndrome
0
1.3
55.6
corneal topography
1
54.9
electrocardiography
4
42.9
cortical thickness
0
6.9
42.6
educational attainment
1
29.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein RP/EB family member 2
VGNC:5181
455369
Macaque
microtubule associated protein RP/EB family member 2
707996
Mouse
MGI:106271
212307
Dog
microtubule associated protein RP/EB family member 2
VGNC:43010
490487
Horse
microtubule associated protein RP/EB family member 2
VGNC:19971
100052621
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein RP/EB family member 2
Macaque
microtubule associated protein RP/EB family member 2
Mouse
Dog
microtubule associated protein RP/EB family member 2
Horse
microtubule associated protein RP/EB family member 2
Publication Statistics
PubMed Score 213.36
PubMed score by year
PubTator Score 41.97
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title