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Tchem
MAPK9
Mitogen-activated protein kinase 9

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Up ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343111
  • ENSP00000345524
  • ENSG00000050748
  • ENST00000393360
  • ENSP00000377028
  • ENST00000425491
  • ENSP00000397422
  • ENST00000452135
  • ENSP00000394560
  • ENST00000455781
  • ENSP00000389338

Symbol
  • JNK2
  • PRKM9
  • SAPK1A
  • JNK2
  • SAPK
  • p54a
  • JNK2A
  • JNK2B
  • PRKM9
  • JNK-55
  • SAPK1a
  • JNK2BETA
  • p54aSAPK
  • JNK2ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
hub protein
1
molecular function
1
kinase perturbation
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.24   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 790   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 354.24   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 790   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 121
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1