MAPK3
Mitogen-activated protein kinase 3
Protein Summary
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel ...more
- ENST00000263025
- ENSP00000263025
- ENSG00000102882
- ENST00000322266
- ENSP00000327293
- ENST00000395199
- ENSP00000378625
- ENST00000395202
- ENSP00000378628
- ERK1
- PRKM3
- ERK1
- ERT2
- ERK-1
- PRKM3
- P44ERK1
- P44MAPK
- HS44KDAP
- HUMKER1A
- p44-ERK1
- p44-MAPK
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
hub protein | 1 | ||
interacting protein | 1 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6557.39 (req: < 5)
Gene RIFs: 967 (req: <= 3)
Antibodies: 1997 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6557.39 (req: >= 5)
Gene RIFs: 967 (req: > 3)
Antibodies: 1997 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 80
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 40
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (40)
Protein-Protein Interactions (1162)
ZDHHC11
Family: Enzyme
Novelty: 0.35249931
p_int: 0.986668658
p_ni: 0.013331342
Score: 0.206
Data Source: BioPlex,STRINGDB
CPLX4
Novelty: 0.1755035
p_int: 0.978478981
p_ni: 0.021521019
Score: 0.229
Data Source: BioPlex,STRINGDB
RNF181
Family: Enzyme
Novelty: 0.27482636
p_int: 0.956767114
p_ni: 0.043232886
Data Source: BioPlex
UXS1
Family: Enzyme
Novelty: 0.04671281
p_int: 0.950592351
p_ni: 0.049407649
Score: 0.172
Data Source: BioPlex,STRINGDB
GPS2
Novelty: 0.00986158
p_int: 0.903651996
p_ni: 0.096347982
p_wrong: 2.2e-8
Score: 0.255
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (31)
Upstream (9)
Downstream (22)
1 – 5 of 9
Pathways (459)
Reactome (136)
KEGG (109)
PathwayCommons (126)
WikiPathways (88)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of NMDA receptors and postsynaptic events | ||||
Reactome | Activation of the AP-1 family of transcription factors | ||||
Reactome | Advanced glycosylation endproduct receptor signaling | ||||
Reactome | Antiviral mechanism by IFN-stimulated genes | ||||
Reactome | Apoptosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of NMDA receptors and postsynaptic events | ||||
Activation of the AP-1 family of transcription factors | ||||
Advanced glycosylation endproduct receptor signaling | ||||
Antiviral mechanism by IFN-stimulated genes | ||||
Apoptosis | ||||
Viral Interactions (0)
Gene Ontology Terms (95)
Functions (9)
Components (15)
Processes (71)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
appendicular lean mass | 2 | 4 | 4 | 94.1 | |||||
multiple sclerosis | 2 | 2 | 0 | 1.1 | 87.9 | ||||
mean corpuscular volume | 3 | 2 | 3 | 85.4 | |||||
body mass index | 2 | 2 | 2 | 84.6 | |||||
red blood cell density measurement | 2 | 1 | 2 | 77.6 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
appendicular lean mass | 4 | 94.1 | |||||
multiple sclerosis | 0 | 1.1 | 87.9 | ||||
mean corpuscular volume | 3 | 85.4 | |||||
body mass index | 2 | 84.6 | |||||
red blood cell density measurement | 2 | 77.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase 3 | VGNC:8987 | 454037 | |||||
Macaque | mitogen-activated protein kinase 3 | 708938 | ||||||
Mouse | MGI:1346859 | 26417 | ||||||
Rat | RGD:3046 | 50689 | ||||||
Dog | mitogen-activated protein kinase 3 | 100855877 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase 3 | |||||
Macaque | mitogen-activated protein kinase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase 3 | |||||
Publication Statistics
PubMed Score 6557.39
PubMed score by year
PubTator Score 6793.44
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (1102)
GeneRif Annotations (967)
Items per page:
0 of 0
PMID | Year | Title |
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