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Tchem
MAPK3
Mitogen-activated protein kinase 3

Protein Summary
Description
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263025
  • ENSP00000263025
  • ENSG00000102882
  • ENST00000322266
  • ENSP00000327293
  • ENST00000395199
  • ENSP00000378625
  • ENST00000395202
  • ENSP00000378628

Symbol
  • ERK1
  • PRKM3
  • ERK1
  • ERT2
  • ERK-1
  • PRKM3
  • P44ERK1
  • P44MAPK
  • HS44KDAP
  • HUMKER1A
  • p44-ERK1
  • p44-MAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6557.39   (req: < 5)
Gene RIFs: 967   (req: <= 3)
Antibodies: 1997   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6557.39   (req: >= 5)
Gene RIFs: 967   (req: > 3)
Antibodies: 1997   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 80
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (1162)
ZDHHC11
Tbio
Family:  Enzyme
Novelty:  0.35249931
p_int:  0.986668658
p_ni:  0.013331342
Score:  0.206
Data Source:  BioPlex,STRINGDB
CPLX4
Tbio
Novelty:  0.1755035
p_int:  0.978478981
p_ni:  0.021521019
Score:  0.229
Data Source:  BioPlex,STRINGDB
SPANXN4
Tdark
Novelty:  1.91062423
p_int:  0.963588317
p_ni:  0.036411683
Data Source:  BioPlex
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.956767114
p_ni:  0.043232886
Data Source:  BioPlex
UXS1
Tbio
Family:  Enzyme
Novelty:  0.04671281
p_int:  0.950592351
p_ni:  0.049407649
Score:  0.172
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.941105443
p_ni:  0.058894557
Data Source:  BioPlex
NPTX2
Tbio
Novelty:  0.00686292
p_int:  0.936298848
p_ni:  0.063701152
Data Source:  BioPlex
ECM1
Tbio
Novelty:  0.00518679
p_int:  0.916115183
p_ni:  0.083884817
Data Source:  BioPlex
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.903651996
p_ni:  0.096347982
p_wrong:  2.2e-8
Score:  0.255
Data Source:  BioPlex,STRINGDB
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.858982958
p_ni:  0.141017042
Data Source:  BioPlex
Nearest Tclin Targets (31)
Explore Nearest Tclin Targets
Pathways (459)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 136
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of the AP-1 family of transcription factors
Reactome
Advanced glycosylation endproduct receptor signaling
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Apoptosis
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Activation of the AP-1 family of transcription factors
Advanced glycosylation endproduct receptor signaling
Antiviral mechanism by IFN-stimulated genes
Apoptosis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (95)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
4
4
94.1
multiple sclerosis
2
2
0
1.1
87.9
mean corpuscular volume
3
2
3
85.4
body mass index
2
2
2
84.6
red blood cell density measurement
2
1
2
77.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
94.1
multiple sclerosis
0
1.1
87.9
mean corpuscular volume
3
85.4
body mass index
2
84.6
red blood cell density measurement
2
77.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 3
VGNC:8987
454037
Macaque
mitogen-activated protein kinase 3
708938
Mouse
MGI:1346859
26417
Rat
RGD:3046
50689
Dog
mitogen-activated protein kinase 3
100855877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase 3
Macaque
mitogen-activated protein kinase 3
Mouse
Rat
Dog
mitogen-activated protein kinase 3
Publication Statistics
PubMed Score 6557.39
PubMed score by year
PubTator Score 6793.44
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title