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Tchem
MAPK10
Mitogen-activated protein kinase 10

Protein Summary
Description
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395157
  • ENSP00000378586
  • ENSG00000109339
  • ENST00000395166
  • ENSP00000378595
  • ENST00000515400
  • ENSP00000424154
  • ENST00000515650
  • ENSP00000492204
  • ENST00000638225
  • ENSP00000491866
  • ENST00000638313
  • ENSP00000492292
  • ENST00000639175
  • ENSP00000491160
  • ENST00000639234
  • ENSP00000491306
  • ENST00000639242
  • ENSP00000491089
  • ENST00000640858
  • ENSP00000491122
  • ENST00000640970
  • ENSP00000492231
  • ENST00000641050
  • ENSP00000493270
  • ENST00000641051
  • ENSP00000493275
  • ENST00000641066
  • ENSP00000493072
  • ENST00000641110
  • ENSP00000493163
  • ENST00000641157
  • ENSP00000493363
  • ENST00000641170
  • ENSP00000493237
  • ENST00000641207
  • ENSP00000493450
  • ENST00000641274
  • ENSP00000492929
  • ENST00000641283
  • ENSP00000493444
  • ENST00000641287
  • ENSP00000493100
  • ENST00000641297
  • ENSP00000493092
  • ENST00000641341
  • ENSP00000493290
  • ENST00000641391
  • ENSP00000493008
  • ENST00000641410
  • ENSP00000493208
  • ENST00000641462
  • ENSP00000493435
  • ENST00000641647
  • ENSP00000493375
  • ENST00000641657
  • ENSP00000493105
  • ENST00000641724
  • ENSP00000493038
  • ENST00000641737
  • ENSP00000493177
  • ENST00000641803
  • ENSP00000493049
  • ENST00000641823
  • ENSP00000493408
  • ENST00000641862
  • ENSP00000493396
  • ENST00000641902
  • ENSP00000492903
  • ENST00000641911
  • ENSP00000493374
  • ENST00000641943
  • ENSP00000492941
  • ENST00000641952
  • ENSP00000493013
  • ENST00000641983
  • ENSP00000493045
  • ENST00000642009
  • ENSP00000493168
  • ENST00000642015
  • ENSP00000493040
  • ENST00000642038
  • ENSP00000492942
  • ENST00000642103
  • ENSP00000493001

Symbol
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1B
  • JNK3
  • JNK3A
  • PRKM10
  • SAPK1b
  • p493F12
  • p54bSAPK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
molecular function
0.99
virus perturbation
0.96
biological process
0.88
pathway
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.91   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 485   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.91   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 485   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 208
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0