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Tdark
MAP6D1
MAP6 domain-containing protein 1

Protein Summary
Description
May have microtubule-stabilizing activity. This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318631
  • ENSP00000314560
  • ENSG00000180834

Symbol
  • SL21
  • MAPO6D1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.7
small molecule perturbation
0.6
cellular component
0.56
cell line
0.54
cell type or tissue
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.79   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.79   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
PARL
Tbio
Family:  Enzyme
Novelty:  0.01317944
Score:  0.708
Data Source:  STRINGDB
VWA5B2
Tdark
Novelty:  1.44975482
Score:  0.636
Data Source:  STRINGDB
YEATS2
Tbio
Novelty:  0.17584498
Score:  0.612
Data Source:  STRINGDB
CORO6
Tdark
Novelty:  0.37416507
Score:  0.582
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.578
Data Source:  STRINGDB
RAPGEFL1
Tdark
Novelty:  1.01382041
Score:  0.545
Data Source:  STRINGDB
CACFD1
Tdark
Novelty:  0.74588749
Score:  0.536
Data Source:  STRINGDB
FAM131A
Tdark
Novelty:  1.91916255
Score:  0.519
Data Source:  STRINGDB
HSPA12B
Tbio
Novelty:  0.06444663
Score:  0.514
Data Source:  STRINGDB
ZNF296
Tbio
Family:  TF
Novelty:  0.25752975
Score:  0.511
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
62.6
body height
1
1
1
42.3
C-reactive protein measurement
1
1
1
33.1
age at menopause
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
62.6
body height
1
42.3
C-reactive protein measurement
1
33.1
age at menopause
1
31.4
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MAP6 domain containing 1
VGNC:1868
460876
Macaque
MAP6 domain containing 1
704767
Mouse
MGI:3607784
208158
Rat
RGD:1560102
363823
Dog
MAP6 domain containing 1
VGNC:53467
111093829
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MAP6 domain containing 1
Macaque
MAP6 domain containing 1
Mouse
Rat
Dog
MAP6 domain containing 1
Publication Statistics
PubMed Score 17.79
PubMed score by year
PubTator Score 2.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title