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Tchem
MAP4K2
Mitogen-activated protein kinase kinase kinase kinase 2

Protein Summary
Description
Serine/threonine-protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Acts as a MAPK kinase kinase kinase (MAP4K) and is an upstream activator of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway and to a lesser extent of the p38 MAPKs signaling pathway. Required for the efficient activation of JNKs by TRAF6-dependent stimuli, including pathogen-associated molecular patterns (PAMPs) such as polyinosine-polycytidine (poly(IC)), lipopolysaccharides (LPS), lipid A, peptidoglycan (PGN), or bacterial flagellin. To a lesser degree, IL-1 and engagement of CD40 also stimulate MAP4K2-mediated JNKs activation. The requirement for MAP4K2/GCK is most pronounced for LPS signaling, and extends to LPS stimulation of c-Jun phosphorylation and induction of IL-8. Enhances MAP3K1 oligomerization, which may relieve N-terminal mediated MAP3K1 autoinhibition and lead to activation following autophosphorylation. Mediates also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294066
  • ENSP00000294066
  • ENSG00000168067
  • ENST00000377350
  • ENSP00000366567

Symbol
  • GCK
  • RAB8IP
  • GCK
  • BL44
  • RAB8IP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
small molecule
0.89
protein domain
0.85
biological process
0.73
histone modification site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.69   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 53
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (30)
DPYSL4
Tbio
Family:  Enzyme
Novelty:  0.0449179
p_int:  0.999999953
p_ni:  1e-9
p_wrong:  4.6e-8
Data Source:  BioPlex
NAA30
Tbio
Family:  Enzyme
Novelty:  0.04701961
p_int:  0.999956365
p_ni:  5.5e-8
p_wrong:  0.00004358
Data Source:  BioPlex
MAP3K1
Tchem
Family:  Kinase
Novelty:  0.0041131
Score:  0.949
Data Source:  STRINGDB
TRAF2
Tbio
Novelty:  0.00983658
Score:  0.942
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.93
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.921
Data Source:  STRINGDB
TNFRSF1A
Tchem
Novelty:  0.00037847
Score:  0.915
Data Source:  STRINGDB
TRADD
Tbio
Novelty:  0.00560091
Score:  0.915
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.905
Data Source:  STRINGDB
RIPK1
Tchem
Family:  Kinase
Novelty:  0.00230565
Score:  0.905
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
17
17
99.5
uric acid measurement
4
3
3
13.8
96.7
renal system measurement
1
1
1
85.7
mean reticulocyte volume
1
1
1
33.1
body mass index
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
17
99.5
uric acid measurement
3
13.8
96.7
renal system measurement
1
85.7
mean reticulocyte volume
1
33.1
body mass index
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 2
VGNC:7507
451301
Macaque
mitogen-activated protein kinase kinase kinase kinase 2
699331
Mouse
MGI:1346883
26412
Rat
RGD:1308199
293694
Dog
mitogen-activated protein kinase kinase kinase kinase 2
VGNC:42982
483759
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase kinase 2
Macaque
mitogen-activated protein kinase kinase kinase kinase 2
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase kinase 2
Publication Statistics
PubMed Score 35.69
PubMed score by year
PubTator Score 6.34
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title