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Tchem
MAP3K8
Mitogen-activated protein kinase kinase kinase 8

Protein Summary
Description
Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263056
  • ENSP00000263056
  • ENSG00000107968
  • ENST00000375321
  • ENSP00000364470
  • ENST00000542547
  • ENSP00000443610

Symbol
  • COT
  • ESTF
  • COT
  • EST
  • ESTF
  • TPL2
  • AURA2
  • MEKK8
  • Tpl-2
  • c-COT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.98
virus perturbation
0.97
PubMedID
0.94
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.59   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 251.59   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0