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Tchem
MAP3K6
Mitogen-activated protein kinase kinase kinase 6

Protein Summary
Description
Component of a protein kinase signal transduction cascade. Activates the JNK, but not ERK or p38 kinase pathways. This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357582
  • ENSP00000350195
  • ENSG00000142733
  • ENST00000374040
  • ENSP00000363152
  • ENST00000493901
  • ENSP00000419591

Symbol
  • ASK2
  • MAPKKK6
  • MEKK6
  • ASK2
  • MEKK6
  • MAPKKK6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.92
gene perturbation
0.88
transcription factor binding site profile
0.79
histone modification site profile
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.4   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0