MAP3K21
Mitogen-activated protein kinase kinase kinase 21
Protein Summary
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
- ENST00000366622
- ENSP00000355581
- ENSG00000143674
- ENST00000366623
- ENSP00000355582
- ENST00000366624
- ENSP00000355583
- KIAA1804
- MLK4
- MLK4
- dJ862P8.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.37 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 208 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.37 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 208 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0