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Tbio
MAP3K21
Mitogen-activated protein kinase kinase kinase 21

Protein Summary
Description
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366622
  • ENSP00000355581
  • ENSG00000143674
  • ENST00000366623
  • ENSP00000355582
  • ENST00000366624
  • ENSP00000355583

Symbol
  • KIAA1804
  • MLK4
  • MLK4
  • dJ862P8.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.8   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.8   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (12)
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.999997196
p_ni:  0.000002798
p_wrong:  6e-9
Score:  0.185
Data Source:  BioPlex,STRINGDB
SLX1A
Tbio
Family:  Enzyme
Novelty:  0.0310173
p_int:  0.99759516
p_ni:  0.000026645
p_wrong:  0.002378195
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.918911369
p_ni:  0.000042568
p_wrong:  0.081046062
Score:  0.195
Data Source:  BioPlex,STRINGDB
PTPRK
Tbio
Family:  Enzyme
Novelty:  0.03149943
Score:  0.597
Data Source:  STRINGDB
TLR4
Tchem
Novelty:  0.00010863
Score:  0.579
Data Source:  STRINGDB
RSPO2
Tbio
Novelty:  0.0188211
Score:  0.538
Data Source:  STRINGDB
CDC7
Tchem
Family:  Kinase
Novelty:  0.00435359
Score:  0.449
Data Source:  STRINGDB
PEX14
Tbio
Novelty:  0.0210557
Score:  0.448
Data Source:  STRINGDB
SLC26A3
Tbio
Family:  Transporter
Novelty:  0.00157687
Score:  0.435
Data Source:  STRINGDB
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.429
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: inoh
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
PathwayCommons: inoh
VEGF signaling pathway ( VEGF signaling pathway )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
PathwayCommons: inoh
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
PathwayCommons: inoh
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Name
Explore in Pharos
Explore in Source
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram )
VEGF signaling pathway ( VEGF signaling pathway )
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) )
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) )
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling )
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
1
1
0
1.3
47.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroid carcinoma
0
1.3
47.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 21
VGNC:53226
469711
Macaque
mitogen-activated protein kinase kinase kinase 21
712755
Mouse
MGI:2385307
234878
Rat
RGD:1306091
307950
Dog
mitogen-activated protein kinase kinase kinase 21
VGNC:52001
100688368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 21
Macaque
mitogen-activated protein kinase kinase kinase 21
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 21
Publication Statistics
PubMed Score 11.80
PubMed score by year
PubTator Score 6.35
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title