MAP3K21
Mitogen-activated protein kinase kinase kinase 21
Protein Summary
Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways.
- ENST00000366622
- ENSP00000355581
- ENSG00000143674
- ENST00000366623
- ENSP00000355582
- ENST00000366624
- ENSP00000355583
- KIAA1804
- MLK4
- MLK4
- dJ862P8.3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.8 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 208 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 11.8 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 208 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (12)
HAVCR2
Novelty: 0.00155885
p_int: 0.999997196
p_ni: 0.000002798
p_wrong: 6e-9
Score: 0.185
Data Source: BioPlex,STRINGDB
SLX1A
Family: Enzyme
Novelty: 0.0310173
p_int: 0.99759516
p_ni: 0.000026645
p_wrong: 0.002378195
Data Source: BioPlex
HIF1AN
Novelty: 0.00861018
p_int: 0.918911369
p_ni: 0.000042568
p_wrong: 0.081046062
Score: 0.195
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
PathwayCommons (5)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: inoh | Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | ||||
PathwayCommons: inoh | VEGF signaling pathway ( VEGF signaling pathway ) | ||||
PathwayCommons: inoh | AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | ||||
PathwayCommons: inoh | AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) | ||||
PathwayCommons: inoh | Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Positive regulation of (Transcription of SOCS by STAT dimer) in JAK STAT pathway ( JAK-STAT pathway and regulation pathway Diagram ) | ||||
VEGF signaling pathway ( VEGF signaling pathway ) | ||||
AKT(PKB)-Bad signaling ( EPO signaling pathway(JAK2 STAT1 STAT3 STAT5) ) | ||||
AKT(PKB)-Bad signaling ( IL-7 signaling(JAK1 JAK3 STAT5) ) | ||||
Drosophila Toll-like receptor signaling ( Drosophila Toll-like receptor signaling ) | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
thyroid carcinoma | 1 | 1 | 0 | 1.3 | 47.7 | ||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
thyroid carcinoma | 0 | 1.3 | 47.7 | ||||
Find similar targets by:
IDG Resources
Data Resources (1)
NanoBRET
- Institute: UNC-CH
- Authors: Julie Pickett
- PI: Tim Willson
- Assay ID: BAO_0010069
- Endpoint: fold change
- Endpoint Detection: fluorescence intensity
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 21 | VGNC:53226 | 469711 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 21 | 712755 | ||||||
Mouse | MGI:2385307 | 234878 | ||||||
Rat | RGD:1306091 | 307950 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 21 | VGNC:52001 | 100688368 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | mitogen-activated protein kinase kinase kinase 21 | |||||
Macaque | mitogen-activated protein kinase kinase kinase 21 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 21 | |||||
Publication Statistics
PubMed Score 11.80
PubMed score by year
PubTator Score 6.35
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (12)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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