Tchem MAP3K20 Mitogen-activated protein kinase kinase kinase 20

Protein Summary

Description

Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189). This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9NYL2
• B3KPG2
• Q53SX1
• Q580W8
• Q59GY5
• Q86YW8
• Q9HCC4
• Q9HCC5
• Q9HDD2
• Q9NYE9

Gene Name

• MAP3K20

Ensembl ID

• ENST00000338983
• ENSP00000340257
• ENSG00000091436
• ENST00000375213
• ENSP00000364361
• ENST00000409176
• ENSP00000387259
• ENST00000539448
• ENSP00000439414

Symbol

• MLTK
• ZAK
• pk
• AZK
• MLT
• MRK
• ZAK
• CNM6
• MLK7
• MLTK
• SFMMP
• mlklak
• MLTKbeta
• MLTKalpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Mitogen-activated Protein Kinase Kinase Kinase 20

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Mlk Family / Mlk Subfamily / Mitogen-activated Protein Kinase Kinase Kinase Mlt

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.12   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.12   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 31

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3