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Tchem
MAP3K15
Mitogen-activated protein kinase kinase kinase 15

Protein Summary
Description
May function in a signal transduction pathway that is activated by various cell stresses and leads to apoptosis. The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338883
  • ENSP00000345629
  • ENSG00000180815

Symbol
  • ASK3
  • ASK3
  • bA723P2.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
protein domain
0.92
tissue sample
0.72
cell line
0.61
phenotype
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (46)
TNFSF13B
Tclin
Novelty:  0.00069885
p_int:  0.999999995
p_ni:  4e-9
Score:  0.197
Data Source:  BioPlex,STRINGDB
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999999947
p_ni:  5.2e-8
p_wrong:  2e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
TAAR5
Tchem
Family:  GPCR
Novelty:  0.05264805
Score:  0.702
Data Source:  STRINGDB
CEMIP2
Tbio
Novelty:  0.04698236
Score:  0.692
Data Source:  STRINGDB
DAB2IP
Tchem
Novelty:  0.01423445
Score:  0.686
Data Source:  STRINGDB
RASAL2
Tbio
Family:  Enzyme
Novelty:  0.03671142
Score:  0.686
Data Source:  STRINGDB
SLC25A43
Tbio
Family:  Transporter
Novelty:  0.21667475
Score:  0.684
Data Source:  STRINGDB
SH3KBP1
Tbio
Family:  Enzyme
Novelty:  0.01454593
Score:  0.66
Data Source:  STRINGDB
FRMD7
Tbio
Novelty:  0.01561885
Score:  0.624
Data Source:  STRINGDB
NYX
Tbio
Novelty:  0.0100148
Score:  0.608
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448588
270672
Dog
mitogen-activated protein kinase kinase kinase 15
VGNC:42971
491765
Horse
mitogen-activated protein kinase kinase kinase 15
VGNC:19934
100058434
Cow
mitogen-activated protein kinase kinase kinase 15
VGNC:31193
529335
Pig
mitogen-activated protein kinase kinase kinase 15
100739216
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
mitogen-activated protein kinase kinase kinase 15
Horse
mitogen-activated protein kinase kinase kinase 15
Cow
mitogen-activated protein kinase kinase kinase 15
Pig
mitogen-activated protein kinase kinase kinase 15
Publication Statistics
PubMed Score 10.11
PubMed score by year
PubTator Score 10.25
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title