MAP3K14
Mitogen-activated protein kinase kinase kinase 14
Protein Summary
Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner. This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor. [provided by RefSeq, Jul 2008]
- ENST00000344686
- ENSP00000478552
- ENSG00000006062
- ENST00000376926
- ENSP00000482657
- ENST00000648527
- ENSP00000497704
- NIK
- HS
- NIK
- HSNIK
- FTDCR1B
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
hub protein | 1 | ||
molecular function | 0.98 | ||
transcription factor binding site profile | 0.88 | ||
biological process | 0.79 | ||
protein domain | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.23 (req: < 5)
Gene RIFs: 64 (req: <= 3)
Antibodies: 318 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 29.23 (req: >= 5)
Gene RIFs: 64 (req: > 3)
Antibodies: 318 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 491
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (491)
Protein-Protein Interactions (174)
CHUK
Family: Kinase
Novelty: 0.00151532
p_int: 0.999999372
p_ni: 6.28e-7
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
IKBKB
Family: Kinase
Novelty: 0.00090202
p_int: 0.999999019
p_ni: 9.8e-7
p_wrong: 1e-9
Score: 0.993
Data Source: BioPlex,STRINGDB
IKBKG
Family: Kinase
Novelty: 0.0006149
p_int: 0.999994493
p_ni: 0.000005485
p_wrong: 2.2e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
TRAF3
Novelty: 0.0022525
p_int: 0.999910945
p_ni: 0.000089004
p_wrong: 5.1e-8
Score: 0.971
Data Source: BioPlex,Reactome,STRINGDB
NAV1
Novelty: 0.00444608
p_int: 0.83075281
p_ni: 0.165095924
p_wrong: 0.004151266
Score: 0.345
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (59)
Reactome (13)
KEGG (11)
PathwayCommons (18)
WikiPathways (17)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
C-type lectin receptors (CLRs) | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
CLEC7A (Dectin-1) signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (6)
Components (5)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (33)
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neuroticism measurement | 2 | 4 | 2 | 7.2 | 80.4 | ||||
heel bone mineral density | 1 | 1 | 1 | 77.4 | |||||
5 | 3 | 0 | 1 | 71.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 67.1 | |||||
platelet crit | 1 | 1 | 1 | 66.8 | |||||
Items per page:
1 – 5 of 33
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neuroticism measurement | 2 | 7.2 | 80.4 | ||||
heel bone mineral density | 1 | 77.4 | |||||
0 | 1 | 71.4 | |||||
myeloid white cell count | 1 | 67.1 | |||||
platelet crit | 1 | 66.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 14 | 716258 | ||||||
Mouse | MGI:1858204 | 53859 | ||||||
Rat | RGD:1310487 | 360640 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 14 | VGNC:42970 | 490926 | |||||
Horse | mitogen-activated protein kinase kinase kinase 14 | VGNC:19933 | 100050140 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 14 | |||||
Horse | mitogen-activated protein kinase kinase kinase 14 | |||||
Publication Statistics
PubMed Score 29.23
PubMed score by year
PubTator Score 175.27
PubTator score by year
Related Publications
Text Mined References (139)
GeneRif Annotations (64)
Items per page:
0 of 0
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