MAP3K14
Mitogen-activated protein kinase kinase kinase 14
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Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
hub protein | 1 | ||
molecular function | 0.98 | ||
transcription factor binding site profile | 0.88 | ||
biological process | 0.79 | ||
protein domain | 0.73 | ||
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
- OR - satisfy the following criterion:
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Target has at least one approved drug - AND - satisfies the preceding conditions
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Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | C-type lectin receptors (CLRs) | ||||
Reactome | CD28 co-stimulation | ||||
Reactome | CD28 dependent PI3K/Akt signaling | ||||
Reactome | CLEC7A (Dectin-1) signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
C-type lectin receptors (CLRs) | ||||
CD28 co-stimulation | ||||
CD28 dependent PI3K/Akt signaling | ||||
CLEC7A (Dectin-1) signaling | ||||
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neuroticism measurement | 2 | 4 | 2 | 7.2 | 80.4 | ||||
heel bone mineral density | 1 | 1 | 1 | 77.4 | |||||
5 | 3 | 0 | 1 | 71.4 | |||||
myeloid white cell count | 1 | 1 | 1 | 67.1 | |||||
platelet crit | 1 | 1 | 1 | 66.8 | |||||
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neuroticism measurement | 2 | 7.2 | 80.4 | ||||
heel bone mineral density | 1 | 77.4 | |||||
0 | 1 | 71.4 | |||||
myeloid white cell count | 1 | 67.1 | |||||
platelet crit | 1 | 66.8 | |||||
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 14 | 716258 | ||||||
Mouse | MGI:1858204 | 53859 | ||||||
Rat | RGD:1310487 | 360640 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 14 | VGNC:42970 | 490926 | |||||
Horse | mitogen-activated protein kinase kinase kinase 14 | VGNC:19933 | 100050140 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | mitogen-activated protein kinase kinase kinase 14 | |||||
Horse | mitogen-activated protein kinase kinase kinase 14 | |||||
PMID | Year | Title |
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