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Tchem
MAP3K12
Mitogen-activated protein kinase kinase kinase 12

Protein Summary
Description
Part of a non-canonical MAPK signaling pathway (PubMed:28111074). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267079
  • ENSP00000267079
  • ENSG00000139625
  • ENST00000547035
  • ENSP00000448689
  • ENST00000547488
  • ENSP00000449038

Symbol
  • ZPK
  • DLK
  • MUK
  • ZPK
  • ZPKP1
  • MEKK12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.95
disease perturbation
0.87
protein domain
0.85
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.91   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 223.91   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 389
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (389)
staurosporine
Rendered image for staurosporine
foretinib
Rendered image for foretinib
GNE-3511
Rendered image for GNE-3511
Indolocarbazole analogue
Rendered image for Indolocarbazole analogue
CHEMBL3355003
Rendered image for CHEMBL3355003
CHEMBL3355005
Rendered image for CHEMBL3355005
GNE-8505
Rendered image for GNE-8505
CHEMBL3733088
Rendered image for CHEMBL3733088
Protein-Protein Interactions (34)
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.949
Data Source:  STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.945
Data Source:  STRINGDB
MAPK14
Tchem
Family:  Kinase
Novelty:  0.00045138
Score:  0.919
Data Source:  STRINGDB
MAPK11
Tchem
Family:  Kinase
Novelty:  0.00545217
Score:  0.917
Data Source:  STRINGDB
PAK1
Tchem
Family:  Kinase
Novelty:  0.00411227
Score:  0.902
Data Source:  STRINGDB
PAK2
Tchem
Family:  Kinase
Novelty:  0.0149123
Score:  0.902
Data Source:  STRINGDB
TARS
Tchem
Family:  Enzyme
Novelty:  0.00795387
Score:  0.803
Data Source:  STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
Score:  0.779
Data Source:  STRINGDB
MBIP
Tbio
Novelty:  0.05807454
Score:  0.769
Data Source:  STRINGDB
TARS2
Tbio
Family:  Enzyme
Novelty:  0.01414012
Score:  0.745
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
3
3
86.3
erythrocyte count
2
2
2
81.2
reticulocyte count
3
3
3
76.7
heel bone mineral density
2
2
2
73.9
red blood cell density measurement
1
1
1
73.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
3
86.3
erythrocyte count
2
81.2
reticulocyte count
3
76.7
heel bone mineral density
2
73.9
red blood cell density measurement
1
73.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 12
VGNC:13213
451940
Macaque
mitogen-activated protein kinase kinase kinase 12
703059
Mouse
MGI:1346881
26404
Rat
RGD:3988
25579
Dog
mitogen-activated protein kinase kinase kinase 12
VGNC:42968
607170
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 12
Macaque
mitogen-activated protein kinase kinase kinase 12
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 12
Publication Statistics
PubMed Score 223.91
PubMed score by year
PubTator Score 92.95
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Year
Title