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Tchem
MAP3K11
Mitogen-activated protein kinase kinase kinase 11

Protein Summary
Description
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle. The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309100
  • ENSP00000309597
  • ENSG00000173327
  • ENST00000530153
  • ENSP00000433886

Symbol
  • MLK3
  • PTK1
  • SPRK
  • MLK3
  • PTK1
  • SPRK
  • MLK-3
  • MEKK11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
disease perturbation
0.97
protein domain
0.97
hub protein
0.92
transcription factor binding site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.01   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 117.01   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (22)
staurosporine
Rendered image for staurosporine
lestaurtinib
Rendered image for lestaurtinib
CHEMBL4465866
Rendered image for CHEMBL4465866
tamatinib
Rendered image for tamatinib
CHEMBL4576489
Rendered image for CHEMBL4576489
URMC-099
Rendered image for URMC-099
K-252a
Rendered image for K-252a
Indolocarbazole analogue
Rendered image for Indolocarbazole analogue
CHEMBL4218417
Rendered image for CHEMBL4218417
Indolocarbazole analogue
Rendered image for Indolocarbazole analogue
Protein-Protein Interactions (109)
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.987
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.963
Data Source:  STRINGDB
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.962
Data Source:  STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.955
Data Source:  STRINGDB
RAC1
Tbio
Family:  Enzyme
Novelty:  0.00365325
Score:  0.953
Data Source:  STRINGDB
MAP4K1
Tchem
Family:  Kinase
Novelty:  0.02861969
Score:  0.951
Data Source:  STRINGDB
LRP8
Tbio
Novelty:  0.00473606
Score:  0.94
Data Source:  STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
Score:  0.937
Data Source:  STRINGDB
RELN
Tbio
Novelty:  0.005326
Score:  0.935
Data Source:  STRINGDB
MAPK8IP2
Tbio
Family:  Enzyme
Novelty:  0.01788453
Score:  0.935
Data Source:  STRINGDB
Pathways (43)
Cytokine Signaling in Immune system (R-HSA-1280215)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (42)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
97.8
heel bone mineral density
3
6
8
95.7
urate measurement
3
3
3
93.3
mean platelet volume
3
2
3
93.2
BMI-adjusted waist-hip ratio
5
5
7
90.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
97.8
heel bone mineral density
8
95.7
urate measurement
3
93.3
mean platelet volume
3
93.2
BMI-adjusted waist-hip ratio
7
90.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 11
VGNC:11916
451326
Mouse
MGI:1346880
26403
Rat
RGD:1359261
309168
Dog
mitogen-activated protein kinase kinase kinase 11
VGNC:42967
483732
Horse
mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitogen-activated protein kinase kinase kinase 11
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 11
Horse
mitogen-activated protein kinase kinase kinase 11 [Source:HGNC Symbol;Acc:HGNC:6850]
Publication Statistics
PubMed Score 117.01
PubMed score by year
PubTator Score 104.76
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title