You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MAP2
Microtubule-associated protein 2

Protein Summary
Description
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199940
  • ENSP00000199940
  • ENSG00000078018
  • ENST00000360351
  • ENSP00000353508
  • ENST00000361559
  • ENSP00000355290
  • ENST00000392194
  • ENSP00000376032
  • ENST00000447185
  • ENSP00000392164

Symbol
  • MAP-2
  • MAP2A
  • MAP2B
  • MAP2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.99
co-expressed gene
0.98
transcription factor perturbation
0.84
cellular component
0.8
disease
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1474.4   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 1220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1474.4   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 1220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
PRKAR2B
Tchem
Family:  Enzyme
Novelty:  0.00456972
p_int:  0.999994914
p_ni:  0.000005084
p_wrong:  2e-9
Score:  0.88
Data Source:  BioPlex,STRINGDB
NUFIP1
Tbio
Novelty:  0.11726869
p_int:  0.999982328
p_ni:  0.000017672
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.99993843
p_ni:  0.000061537
p_wrong:  3.3e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
DGUOK
Tbio
Family:  Kinase
Novelty:  0.00897987
p_int:  0.999291837
p_ni:  0.000437589
p_wrong:  0.000270574
Data Source:  BioPlex
ARMC1
Tbio
Novelty:  0.02018109
p_int:  0.997458158
p_ni:  0.002541764
p_wrong:  7.9e-8
Score:  0.165
Data Source:  BioPlex,STRINGDB
MARK2
Tchem
Family:  Kinase
Novelty:  0.00437762
Score:  0.934
Data Source:  STRINGDB
BRSK2
Tchem
Family:  Kinase
Novelty:  0.01531371
Score:  0.921
Data Source:  STRINGDB
BRSK1
Tchem
Family:  Kinase
Novelty:  0.0267976
Score:  0.917
Data Source:  STRINGDB
GFAP
Tbio
Novelty:  0.00020932
Score:  0.835
Data Source:  STRINGDB
SYP
Tbio
Novelty:  0.00021543
Score:  0.83
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
40.7
insomnia measurement
1
1
0
1
21.5
handedness
1
1
0
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
40.7
insomnia measurement
0
1
21.5
handedness
0
1
0.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 2
VGNC:1994
459909
Macaque
microtubule associated protein 2
710840
Mouse
MGI:97175
17756
Rat
RGD:3044
25595
Dog
microtubule associated protein 2
VGNC:42959
488504
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microtubule associated protein 2
Macaque
microtubule associated protein 2
Mouse
Rat
Dog
microtubule associated protein 2
Publication Statistics
PubMed Score 1474.40
PubMed score by year
PubTator Score 1052.40
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title